A Case Report of Interferon β Monotherapy for High Hepatitis C Viral Load in Dialysis Patients
Article first published online: 26 JUL 2007
Therapeutic Apheresis and Dialysis
Volume 11, Issue 4, pages 306–308, August 2007
How to Cite
Nakajima, F., Fukii, M., Kitamura, T., Sakaida, A., Sakaguchi, M., Oka, H., Morimoto, S., Masaki, H., Yamahara, H., Shibahara, N. and Inoue, T. (2007), A Case Report of Interferon β Monotherapy for High Hepatitis C Viral Load in Dialysis Patients. Therapeutic Apheresis and Dialysis, 11: 306–308. doi: 10.1111/j.1744-9987.2007.00488.x
- Issue published online: 26 JUL 2007
- Article first published online: 26 JUL 2007
- Received August 2006; revised November 2006.
- Hepatitis C virus;
- Interferon β
Abstract: A 42-year-old male dialysis patient was infected with hepatitis C virus (HCV), and treated with interferon β (IFN-β) for a rapid increase in viral load. After dialysis three times a week, 3 million units of IFN-β were intravenously infused for 1 h. The treatment was markedly effective, and the virus was eliminated in the sixth week. Therapy was continued for 24 weeks, and HCV negativity has been maintained for more than 6 months after the completion of administration. The blood IFN level slowly decreased immediately after administration. The mean trough level was 37 U/mL, and the half-life was 65 min. No adverse event requiring discontinuation of the treatment occurred, showing that IFN alone may safely eliminate the virus in dialysis patients with high hepatitis C viral load. Many dialysis patients are latently infected with HCV, and the infection affects the prognosis. Therefore, establishment of a therapeutic method is urgently needed.