Difficulty in Improving Malnutrition and Low-grade Inflammation in Diabetic Patients on Peritoneal Dialysis

  1. Sung-Won Park1,2,
  2. Jung-Ju Seo1,
  3. Ho-Sang Bae1,
  4. Jong-Yeon Kim1,
  5. Chan-Duck Kim1,
  6. Sun-Hee Park1,
  7. Yong-Lim Kim1

Article first published online: 30 DEC 2008

DOI: 10.1111/j.1744-9987.2008.00638.x

Issue

Therapeutic Apheresis and Dialysis

Therapeutic Apheresis and Dialysis

Volume 12, Issue 6, pages 475–483, December 2008

Additional Information

How to Cite

Park, S.-W., Seo, J.-J., Bae, H.-S., Kim, J.-Y., Kim, C.-D., Park, S.-H. and Kim, Y.-L. (2008), Difficulty in Improving Malnutrition and Low-grade Inflammation in Diabetic Patients on Peritoneal Dialysis. Therapeutic Apheresis and Dialysis, 12: 475–483. doi: 10.1111/j.1744-9987.2008.00638.x

Author Information

  1. 1

    Department of Internal Medicine, Kyungpook University Hospital, Daegu and

  2. 2

    Department of Internal Medicine, Andong Hospital, Andong, South Korea

*Professor Yong-Lim Kim, Department of Internal Medicine, Kyungpook University Hospital, 50 Samduck-dong, Jung-gu, Daegu, 700-721, South Korea. Email: ylkim@knu.ac.kr

Publication History

  1. Issue published online: 30 DEC 2008
  2. Article first published online: 30 DEC 2008
  3. Received November 2007; revised March 2008.

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Keywords:

  • Diabetes mellitus;
  • Inflammation;
  • Nutrition;
  • Peritoneal dialysis;
  • Peritoneal transport characteristic

Abstract

Continuous ambulatory peritoneal dialysis (CAPD) is commonly used for renal replacement therapy in diabetes mellitus (DM) patients. We investigated the changes of peritoneal transport characteristics, nutritional status, and adequacy and inflammation parameters in diabetic CAPD patients (N = 17) compared to non-diabetic patients (N = 23). Peritoneal equilibrium testing, nutritional, biochemical, and anthropometric parameters and adequacy were prospectively assessed at 1 (baseline), 6 and 12 months after initiating CAPD. The levels of several nutritional parameters were lower and did not change in DM patients over time (P < 0.05) and significantly improved in the non-DM patients over time (P < 0.05). Total weekly creatinine clearance and residual renal function exhibited a rapid decline (P < 0.05) and inflammation parameter levels were higher in DM patients (P < 0.05). Our results showed the difficulty in improvement of nutritional status and inflammatory parameters in diabetic patients during at least the first year of CAPD compared to non-DM patients.

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