Italian Multicenter Study on Low-Density Lipoprotein Apheresis (IMS-LDLa) Working Group (presented for each center involved in the study): L'Aquila: Luigi Dell'Orso, Unit of Immunohematology and Transfusion Medicine, “S Salvatore” Hospital, L'Aquila Bari 1: Alfonso Ramunni, Nephrology 1, Department of Internal Medicine and Public Medicine, University of Bari Bari 2: Tommaso De Palo, Unit of Pediatric Nephrology and Dialysis, “Giovanni XXIII” Hospital, Bari Cagliari: Paolo Pintus and Sandra Anedda, Center of Metabolic and Atherosclerotic Disease, “G Brotzu” Hospital Milan: Ghil Busnach, Unit of Nephrology, Dialysis and Renal Transplantation Therapy, “Niguarda Ca'Granda” Hospital Nuoro: Patrizia Vatieri, Unit of Nephrology and Dialysis, “San Francesco” Hospital Padova: Giustina De Silvestro and Piero Marson, Unit of Immunotransfusional Medicine, Padova Hospital, University of Padova Palermo: Rosalia Agliastro, Unit of Immunohematology and Transfusion Medicine, “G Di Cristina e M Ascoli” Hospital Pistoia: Giovanna D'Alessandri and Adriana Tognaccini, Unit of Immunohematology and Transfusion Medicine, Azienda USL 3, Pistoia Prato: Amato Marcello, Department of Nephrology, Azienda USL 4, Prato Hospital Reggio Emilia: Gianpaolo Russi, Unit of Transfusion Medicine and Immunohematology, “Santa Maria Nuova” Hospital Rome: Claudia Stefanutti (coordinator and corresponding author) and Serafina Di Giacomo, Department of Clinical and Medical Therapy, Plasmapheresis Unit, University of Rome “La Sapienza”, “Umberto I” Hospital Sassari 1: Giuseppe Piredda, Anesthesia and Intensive Care, University of Sassari Sassari 2: Maria Cossu and Pietro Giorgio Pala, Unit of Nephrology, Dialysis and Transplantation, Azienda USL 1, “SS Annunziata” Hospital Sassari 3 (Ozieri): Luciangela Calvisi, Unit of Nephrology and Dialysis, “Antonio Segni” Hospital Trieste: Luigi Cattin and Maurizio Fonda, Medicine III, Service of Diabetes and Metabolic Diseases, Cattinara Hospital Ospedali Riuniti Di Trieste Varese (Gallarate): Lorella Poli, Unit of Transfusion Medicine and Immunohematology, “S Antonio Abate” Hospital Verona: Maria Grazia Zenti, Endocrinology and Metabolic Diseases, “Civile Maggiore” Hospital Viterbo: Maria Rita Guitarrini, Department of Transfusion Medicine, North Lazio Azienda USL Viterbo, “Bel Colle” Hospital
Italian Multicenter Study on Low-Density Lipoprotein Apheresis: Retrospective Analysis (2007)
Article first published online: 17 JUL 2009
© 2009 The Authors. Journal compilation © 2009 International Society for Apheresis
Therapeutic Apheresis and Dialysis
Volume 14, Issue 1, pages 79–86, February 2010
How to Cite
Stefanutti, C. and the Italian Multicenter Study on Low-density Lipoprotein Apheresis Working Group (2010), Italian Multicenter Study on Low-Density Lipoprotein Apheresis: Retrospective Analysis (2007). Therapeutic Apheresis and Dialysis, 14: 79–86. doi: 10.1111/j.1744-9987.2009.00704.x
- Issue published online: 12 FEB 2010
- Article first published online: 17 JUL 2009
- Received January 2009; revised February 2009.
- Coronary artery disease;
- Low-density lipoprotein apheresis;
- Multicenter study
A retrospective study—the Italian Multicenter Study on Low-density Lipoprotein Apheresis (IMS-LDLa)—was carried out, which involved 19 centers for LDLa in Italy, distributed all over the country—in the north, center, south, and the major islands. The survey was conducted through two consecutive questionnaires, which can be downloaded online from a dedicated site. The total number of procedures performed until 2007 was 31 012, and the number of patients undergoing treatment until 2007 were 229. The treated patients still surviving consisted of 136 (74 males and 62 females); those surviving but not treated numbered 95, and those deceased numbered 14. The techniques utilized, listed by frequency of use, were the following: dextran sulfate cellulose adsorption, direct adsorption of lipids (DALI), heparin extracorporeal LDL precipitation, immunoadsorption, plasma-exchange, cascade filtration, and Lipocollect 200. The mean treated plasma and blood volumes per session were 3916.5 mL and 8735.1 mL, respectively. The most frequently utilized vascular access points were: venous 84.4% and arteriovenous fistula 15.5%. Hematoma by venipuncture (230 episodes), low outlet flow (125 episodes), and circuit coagulation (44 episodes) were reported as to be the most frequent side effects. In the second questionnaire (filled in by 19 centers) the centers were asked to report their data on: quality diagnosis of dyslipidemia and referents for genetic-molecular and clinical diagnosis, cholesterol-lowering drugs and dosages, typology of cardiovascular check-ups at the beginning of treatment and in follow-up, non-cholesterol-lowering drugs with priority for cardiologic drugs, including oral anti-coagulants, and, lastly, information related to the appropriateness of curing patients still under treatment with LDLa and, where possible, news on patients no longer under treatment.