A Case Report of Thrombocytopenia-associated Multiple Organ Failure Secondary to Salmonella enterica Serotype Typhi Infection in a Pediatric Patient: Successful Treatment With Plasma Exchange
Article first published online: 26 MAR 2010
© 2010 The Authors. Journal compilation © 2010 International Society for Apheresis
Therapeutic Apheresis and Dialysis
Volume 14, Issue 2, pages 226–229, April 2010
How to Cite
Yildirim, I., Ceyhan, M., Bayrakci, B., Uysal, M., Kuskonmaz, B. and Ozaltin, F. (2010), A Case Report of Thrombocytopenia-associated Multiple Organ Failure Secondary to Salmonella enterica Serotype Typhi Infection in a Pediatric Patient: Successful Treatment With Plasma Exchange. Therapeutic Apheresis and Dialysis, 14: 226–229. doi: 10.1111/j.1744-9987.2009.00714.x
- Issue published online: 26 MAR 2010
- Article first published online: 26 MAR 2010
- Received March 2009; Revised April 2009.
- Plasma exchange;
- Salmonella enterica serotype Typhi;
- Thrombocytopenia-associated multiple organ failure
A high proportion of the patients with Salmonella enterica serotype Typhi infection develop severe sepsis. The mortality rate is high despite aggressive antimicrobial therapy in these patients. The case of a 10-year-old boy who developed thrombocytopenia-associated multiple organ failure (TAMOF) secondary to S. typhi infection is reported. The patient did not respond to antimicrobial treatment, including ciprofloxacin, in addition to conventional supportive measures, so plasma exchange was performed. The thrombocytopenia and organ failure had resolved after 3 days of plasma exchange therapy. Plasma exchange is suggested to be a life-saving intervention in a child with TAMOF secondary to S. typhi infection.