Presented in part at the 29th Annual Meeting of the Japanese Society for Apheresis held November 21–23, 2008, in Hiroshima, Japan.
Intermittent Plasmapheresis Prevents Recurrence in Neuromyelitis Optica
Version of Record online: 26 NOV 2009
© 2009 The Authors. Journal compilation © 2009 International Society for Apheresis
Therapeutic Apheresis and Dialysis
Volume 13, Issue 6, pages 505–508, December 2009
How to Cite
Miyamoto, K. and Kusunoki, S. (2009), Intermittent Plasmapheresis Prevents Recurrence in Neuromyelitis Optica. Therapeutic Apheresis and Dialysis, 13: 505–508. doi: 10.1111/j.1744-9987.2009.00780.x
- Issue online: 26 NOV 2009
- Version of Record online: 26 NOV 2009
- Received February 2009.
- Multiple sclerosis;
- Neuromyelitis optica;
Neuromyelitis optica (NMO) is a relapsing inflammatory condition characterized by selective involvement of the optic nerves and spinal cord. Humoral immune mechanisms play a role in the pathogenesis of NMO. The therapeutic efficacy of plasmapheresis (PP) has been reported in the cases that were poorly controlled with other treatments. Herein, we report four patients with NMO who underwent PP following intensive intravenous corticosteroid therapy. All patients showed definite functional improvement following one to five plasma exchanges. To prevent relapse, these patients were treated with oral prednisolone in combination with azathioprine or cyclophosphamide. Two of the four patients also underwent intermittent PP because treatment with oral agents was unsuccessful. In conclusion, when treatment with oral immunosuppressants is ineffective in reducing recurrences of NMO, an additional PP session should be attempted.