Effects of In-Center Nocturnal Versus Conventional Hemodialysis on Endothelial Dysfunction
Article first published online: 11 MAY 2012
© 2012 The Authors. Therapeutic Apheresis and Dialysis © 2012 International Society for Apheresis
Therapeutic Apheresis and Dialysis
Volume 16, Issue 4, pages 334–340, August 2012
How to Cite
Jin, X., Rong, S., Mei, C., Ye, C., Chen, J. and Chen, X. (2012), Effects of In-Center Nocturnal Versus Conventional Hemodialysis on Endothelial Dysfunction. Therapeutic Apheresis and Dialysis, 16: 334–340. doi: 10.1111/j.1744-9987.2012.01070.x
- Issue published online: 22 JUL 2012
- Article first published online: 11 MAY 2012
- Received November 2011; revised February 2012.
- Cardiovascular disease;
- Conventional hemodialysis;
- Endothelium dysfunction;
- Flow-mediated dilation;
- In-center nocturnal hemodialysis
Cardiovascular disease is the leading cause of morbidity and mortality in patients with end-stage renal disease who undergo hemodialysis and endothelial dysfunction is an early key step in the development of atherosclerosis. The aim of this study was to investigate the effect of thrice-weekly in-center nocturnal hemodialysis (INHD, 8 h per session and three sessions per week) and conventional hemodialysis (CHD, 4 h per session and three sessions per week) on endothelial dysfunction in patients with end-stage renal disease. 32 INHD and 58 matched CHD patients were enrolled, baseline and 12-month measures of blood pressure (BP), serum calcium and phosphorus, serum intact PTH (iPTH) and brachial artery flow-mediated dilation (FMD) were collected and analyzed. Baseline characteristics were similar between groups except that serum phosphorus and calcium × phosphorus were higher in the INHD group. At the 12-month follow-up, there was a significant increase in FMD (6.0 ± 1.5% to 7.1 ± 1.8%, P < 0.01) in INHD patients. Multivariate analysis showed that FMD was inversely correlated with systolic BP (SBP) (β = −0.485, P < 0.01), diastolic BP (DBP) (β = −0.428, P < 0.01), iPTH (β = −0.405, P < 0.01) and serum phosphorus level (β = −0.375, P < 0.01). There was no significant change in FMD in the CHD group. Compared with CHD, INHD improves endothelial function, and control of serum phosphorus is associated with the improvement of endothelial function.