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SCREENING OF SOME INDIAN MEDICINAL PLANT EXTRACTS FOR THEIR ANTIHYPERGLYCEMIC ACTIVITIES IN STREPTOZOTOCIN-INDUCED DIABETIC MICE

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Abstract

ABSTRACT

Plants have been an exemplary source of medicines. In the present study, antidiabetic potential of some common Indian medicinal plants, Tinospora cordifolia, Phyllanthus emblica, Murraya koenigii, Capparis decidua, Eugenia jambolana, Aegel marmelos, Pterocarpus marsupium, Eucalyptus globulus, and Commiphora mukul were analyzed by gavaging 100 mg/kg body weight/day of each plant extracts to streptozotocin-induced diabetic mice. Different biochemical parameters like fasting blood glucose level, glucose tolerance test, lipid profile and glycogen biosynthesis were all significantly improved as compared with diabetic and normal animals (P < 0.05). The activity of glucose-6-phosphatase enzyme which regulates glucose homeostasis was also significantly altered (P < 0.05). These data showed that all these plant extracts have varying degree of antidiabetic and antihyperlipidemic activities.

PRACTICAL APPLICATIONS

Medicinal plants provide an effective and potential source of hypoglycemic drugs and many compounds and extracts derived from plants have been used in the treatment of diabetes. Medicinal plants in the form of extract or herbal formulation have been investigated for their therapeutic potential using modern scientific approach and several active molecules have been isolated, identified and studied for their role in diabetes treatment. This preliminary screening system thus provided a platform where the potential plants demonstrating antidiabetic activities could be selected to further analyze in detail and understand their mechanism(s) of action.

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