Plants have been an exemplary source of medicines. In the present study, antidiabetic potential of some common Indian medicinal plants, Tinospora cordifolia, Phyllanthus emblica, Murraya koenigii, Capparis decidua, Eugenia jambolana, Aegel marmelos, Pterocarpus marsupium, Eucalyptus globulus, and Commiphora mukul were analyzed by gavaging 100 mg/kg body weight/day of each plant extracts to streptozotocin-induced diabetic mice. Different biochemical parameters like fasting blood glucose level, glucose tolerance test, lipid profile and glycogen biosynthesis were all significantly improved as compared with diabetic and normal animals (P < 0.05). The activity of glucose-6-phosphatase enzyme which regulates glucose homeostasis was also significantly altered (P < 0.05). These data showed that all these plant extracts have varying degree of antidiabetic and antihyperlipidemic activities.