Swietenia mahagony extract shows agonistic activity to PPAR γ and gives ameliorative effects on diabetic db/db mice

Authors

  • Dan-dan LI,

    1. Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;
    2. Chemistry Department, Tongji University, Shanghai 200092, China;
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    • 5

      These authors contributed equally to this work.

  • Jun-hua CHEN,

    1. Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;
    2. Graduate School of the Chinese Academy of Sciences, China
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    • 5

      These authors contributed equally to this work.

  • Qing CHEN,

    1. Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;
    2. Graduate School of the Chinese Academy of Sciences, China
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  • Guo-wei LI,

    1. Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;
    2. Graduate School of the Chinese Academy of Sciences, China
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  • Jing CHEN,

    1. Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;
    2. Graduate School of the Chinese Academy of Sciences, China
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  • Jian-min YUE,

    1. Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;
    2. Graduate School of the Chinese Academy of Sciences, China
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  • Min-li CHEN,

    1. Animal Experiment Center, Zhejiang College of Traditional Chinese Medicine, Hangzhou 310053, China;
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  • Xiao-ping WANG,

    1. Chemistry Department, Tongji University, Shanghai 200092, China;
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  • Jian-hua SHEN,

    Corresponding author
    1. Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;
    2. Graduate School of the Chinese Academy of Sciences, China
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  • Xu SHEN,

    Corresponding author
    1. Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;
    2. Graduate School of the Chinese Academy of Sciences, China
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  • Hua-liang JIANG

    Corresponding author
    1. Drug Discovery and Design Center, State Key Lab of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China;
    2. Graduate School of the Chinese Academy of Sciences, China
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Correspondence to Prof Jian-hua SHEN
E-mail jhshen@mail.shcnc.ac.cn; Prof Xu SHEN
E-mail xshen@mail.shcnc.ac.cn;
Prof Hua-liang JIANG
hljiang@mail.shcnc.ac.cn
Phn 86-21-5080-6600.
Fax 86-21-5080-7088.

Abstract

Aim: To search the peroxisome proliferator-activated receptor γ (PPARγ) agonists from Swietenia mahagony extract (SmE) and observe the possible ameliorative effects of SmE on diabetic db/db mice.

Methods: The PPARγ agonistic activity of SmE was screened by yeast-two hybrid system. The blood glucose levels of diabetic db/db mice were measured using a blood glucose level monitor and the data were statistically analyzed by NDST8.8W software.

Results: By using the clinical drug rosiglitazone as a positive control, it was found that the PPARγ agonistic activity of SmE at a concentration of 50 μg/L was approximately half that of 35.7 μg/L (0.1 μmol/L) of rosiglitazone. At the dose of 1000 mg/kg, SmE remarkably decreased the blood glucose concentration of db/db mice from (15.26±2.98) to (7.58±2.20) mmol/L, and reduced the blood glucose levels by 55.49% compared with the control group (P<0.01).

Conclusion: SmE shows agonistic activity to PPARγ and can ameliorate the blood glucose levels of diabetic db/db mice. SmE may be thus used as a potential agent for diabetes therapy.

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