Project supported by the National Natural Foundation of China (No 3057 0592, 30670693, and 30700222).
Glial involvement in trigeminal central sensitization1
Article first published online: 3 JUN 2008
© 2008 CPS and SIMM
Acta Pharmacologica Sinica
Volume 29, Issue 6, pages 641–645, June 2008
How to Cite
XIE, Y.-f. (2008), Glial involvement in trigeminal central sensitization. Acta Pharmacologica Sinica, 29: 641–645. doi: 10.1111/j.1745-7254.2008.00801.x
- Issue published online: 3 JUN 2008
- Article first published online: 3 JUN 2008
- Received 2008-01-30 Accepted 2008-03-12
- central sensitization
Recent studies have indicated that trigeminal neurons exhibit central sensitization, an increase in the excitability of neurons within the central nervous system to the extent that a normally innocuous stimulus begins to produce pain after inflammation or injury, and that glial activities play a vital role in this central sensitization. The involvement of glial cells in trigeminal central sensitization contains multiple mechanisms, including interaction with glutamatergic and purinergic receptors. A better understanding of the trigeminal central sensitization mediated by glial cells will help to find potential therapeutic targets and lead to developing new analgesics for orofacial-specific pain with higher efficiency and fewer side-effects.