Significant reduction of sperm disomy in six men: effect of traditional Chinese medicine?

  1. Helen G. Tempest1,
  2. Sheryl T. Homa2,
  3. Xiao-Ping Zhai2,
  4. Darren K. Griffin1,*

Article first published online: 7 DEC 2005

DOI: 10.1111/j.1745-7262.2005.00068.x

Issue

Asian Journal of Andrology

Asian Journal of Andrology

Volume 7, Issue 4, pages 419–425, December 2005

Additional Information

How to Cite

Tempest, H. G., Homa, S. T., Zhai, X.-P. and Griffin, D. K. (2005), Significant reduction of sperm disomy in six men: effect of traditional Chinese medicine?. Asian Journal of Andrology, 7: 419–425. doi: 10.1111/j.1745-7262.2005.00068.x

Author Information

  1. 1

    Department of Biosciences, University of Kent, Canterbury CT2 7NJ, UK

  2. 2

    Ten Harley Street, London W1G 9PF, UK

*Corresponence to: Dr Darren K. Griffin, Department of Biosciences, University of Kent, Canterbury CT2 7NJ, UK. Tel: +44-1227-823022, Fax: +44-1227-763-912 E-mail: d.k.griffin@kent.ac.uk

Publication History

  1. Issue published online: 7 DEC 2005
  2. Article first published online: 7 DEC 2005
  3. Received 2005-02-24 Accepted 2005-07-06

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Keywords:

  • traditional Chinese medicine;
  • sperm disomy;
  • chromosome;
  • male infertility

Abstract

Aim: To test the hypothesis that levels of sperm disomy fell significantly in six men treated by traditional Chinese medicine (TCM).

Methods: Fluorescence in situ hybridization (FISH) was done on the sperm heads of six men before and during treatment by TCM.

Results: There was a significant reduction in sperm disomy in all six men. This coincided with TCM treatment.

Conclusion: This is the first study reporting a significant reduction in sperm disomy in men over a given time course. The fact that this coincided with TCM treatment is intriguing but no conclusions can be drawn from this until placebo-controlled clinical trials are implemented.

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