Relationship between XRCC1 polymorphisms and susceptibility to prostate cancer in men from Han, Southern China

  1. Zheng Xu1,
  2. Li-Xin Hua1,
  3. Li-Xin Qian1,
  4. Jie Yang1,
  5. Xin-Ru Wang2,
  6. Wei Zhang1,
  7. Hong-Fei Wu1

Article first published online: 9 MAY 2007

DOI: 10.1111/j.1745-7262.2007.00263.x

Issue

Asian Journal of Andrology

Asian Journal of Andrology

Volume 9, Issue 3, pages 331–338, May 2007

Additional Information

How to Cite

Xu, Z., Hua, L.-X., Qian, L.-X., Yang, J., Wang, X.-R., Zhang, W. and Wu, H.-F. (2007), Relationship between XRCC1 polymorphisms and susceptibility to prostate cancer in men from Han, Southern China. Asian Journal of Andrology, 9: 331–338. doi: 10.1111/j.1745-7262.2007.00263.x

Author Information

  1. 1

    Department of Urology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

  2. 2

    School of Public Health, Nanjing Medical University, Nanjing 210029, China

* Dr Hong-Fei Wu, Department of Urology, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Rd., Nanjing 210029, China. Tel: +86-25-8371-8836 ext. 6603 Fax: +86-25-8378-0079 E-mail: wu-hongfei@hotmail.com

Publication History

  1. Issue published online: 9 MAY 2007
  2. Article first published online: 9 MAY 2007
  3. Received 2006-08-29 Accepted 2006-11-08

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (143K)

Keywords:

  • XRCC1;
  • polymorphism;
  • prostate cancer;
  • genetic susceptibility;
  • molecular epidemiology

Abstract

Aim: To investigate the association among XRCC1 polymorphisms, smoking, drinking and the risk of prostate cancer (PCa) in men from Han, Southern China. Methods: In a case-control study of 207 patients with PCa and 235 cancer-free controls, frequency-matched by age, we genotyped three XRCC1 polymorphisms (codons 194, 280 and 399) using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RELP) method. Results: Among the three polymorphisms, we found that the XRCC1 Arg399Gln variant allele was associated with increased PCa risk (adjusted odd ratio [OR]: 1.67, 95% confident interval [CI]: 1.11-2.51), but the XRCC1 Arg194Trp variant allele had a 38% reduction in risk of PCa (adjusted OR: 0.62, 95% CI: 0.41-0.93). However, there was no significant risk of PCa associated with Arg280His polymorphism. When we evaluated the three polymorphisms together, we found that the individuals with 194Arg/Arg wild-type genotype, Arg280His and Arg399Gln variant genotypes had a significantly higher risk of PCa (adjusted OR: 4.31; 95% CI: 1.24-14.99) than those with three wild-type genotypes. In addition, we found that Arg399Gln variant genotypes had a significant risk of PCa among heavy smokers (adjusted OR: 2.04; 95% CI: 1.03-4.05). Conclusion: These results suggest that polymorphisms of XRCC1 appear to influence the risk of PCa and may modify risks attributable to environmental exposure.

Get PDF (143K)