• 1
    Landis SH, Murray T, Bolden S, Wingo PA. Cancer statistics CA Cancer. J Clin 1999; 49: 831.
  • 2
    Burkhardt JH, Litwin MS, Rose CM, Correa RJ, Sunshine JH, Hogan C, et al. Comparing the costs of radiation therapy and radical prostatectomy for the initial treatment of early-stage prostate cancer. J Clin Oncol 2002; 20: 286975.
  • 3
    Jochen W, Salomon G, Perrotte P. Prevalence of erectile dysfunction in a prostate cancer screening population. American Urological Association (AUA) 2007 Annual Meeting. May 19–24, 2007, Anaheim, CA, USA. J Urol 2007; 177 (4 Suppl): Abstract 1035.
  • 4
    Penson DF, McLerran D, Feng Z, Li L, Albertsen PC, Gilliland FD, et al. 5-year urinary and sexual outcomes after radical prostatectomy: results from the prostate cancer outcomes study. J Urol 2005; 173: 17015.
  • 5
    Walsh PC, Marschke P, Ricker D, Burnett AL. Patient-reported urinary continence and sexual function after anatomic radical prostatectomy. Urology 2000; 55: 5861.
  • 6
    Kao TC, Cruess DF, Garner D, Foley J, Seay T, Friedrichs P, et al. Multicenter patient self-reporting questionnaire on impotence, incontinence and stricture after radical prostatectomy. J Urol 2000; 163: 85864.
  • 7
    Jonler M, Ritter MA, Brinkmann R, Messing EM, Rhodes PR, Bruskewitz RC, et al. Sequelae of definitive radiation therapy for prostate cancer localized to the pelvis. Urology 1994; 44: 87682.
  • 8
    Jonler M, Nielsen OS, Wolf H. Urinary symptoms, potency, and quality of life in patients with localized prostate cancer followed up with deferred treatment. Urology 1998; 52: 105562; discussion 1063.
  • 9
    Kendirci M, Bejma J, Hellstrom WJ. Update on erectile dysfunction in prostate cancer patients. Curr Opin Urol 2006; 16: 18695.
  • 10
    Walsh PC, Donker PJ. Impotence following radical prostatectomy: insight into etiology and prevention. 1982. J Urol 2002; 167 (2 Pt 2): 100510.
  • 11
    Young HH. The early diagnosis and radical cure of carcinoma of the prostate. Being a study of 40 cases and presentation of a radical operation which was carried out in four cases. 1905. J Urol 2002; 168: 91421.
  • 12
    Quinlan DM, Epstein JI, Carter BS, Walsh PC. Sexual function following radical prostatectomy: influence of preservation of neurovascular bundles. J Urol 1991; 145: 9981002.
  • 13
    Impotence. NIH Consens Statement 1992; 10: 1.
  • 14
    Walsh PC, Mostwin JL. Radical prostatectomy and cystoprostatectomy with preservation of potency. Results using a new nerve-sparing technique. Br J Urol 1984; 56: 6947.
  • 15
    Fleischmann JD, Catalona WJ. Endocrine therapy for bladder outlet obstruction from carcinoma of the prostate. J Urol 1985; 134: 498500.
  • 16
    Pontes J E, Huben R, Wolf R. Sexual function after radical prostatectomy. Prostate 1986; 8: 1236.
  • 17
    Narayan P. Nerve sparing and continence preservation during radical prostatectomy. Urol Int 1991; 46: 26674.
  • 18
    Loughlin KR, O'Leary, MP. Re: Oral androgens in the treatment of hypogonadal impotent men. J Urol 1995; 153: 1645.
  • 19
    Krupski TL, Saigal CS, Litwin MS. Variation in continence and potency by definition. J Urol 2003; 170 (4 Pt 1): 12914.
  • 20
    Stanford JL, Feng Z, Hamilton AS, Gilliland FD, Stephenson RA, Eley JW, et al. Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: the Prostate Cancer Outcomes Study. JAMA 2000; 283: 35460.
  • 21
    Ayajiki K, Toda N, Okamura T. Nitroxidergic (nitrergic) nerve and erectile dysfunction. Nippon Yakurigaku Zasshi 2002; 119: 218.
  • 22
    Williams BA, Liu C, Deyoung L, Brock GB, Sims SM. Regulation of intracellular Ca2+ release in corpus cavernosum smooth muscle: synergism between nitric oxide and cGMP. Am J Physiol Cell Physiol 2005; 288: C6508.
  • 23
    Ruiz Rubio JL, Hernandez M, Rivera de los Arcos L, Martinez AC, Garcia-Sacristan A, Prieto D. Mechanisms of prostaglandin E1-induced relaxation in penile resistance arteries. J Urol 2004; 171 (2 Pt 1): 96873.
  • 24
    Lin JS, Lin YM, Jou YC, Cheng JT. Role of cyclic adenosine monophosphate in prostaglandin E1-induced penile erection in rabbits. Eur Urol 1995; 28: 25965.
  • 25
    Lue TF, Takamura T, Schmidt RA, Tanagho EA. Potential preservation of potency after radical prostatectomy. Urology 1983; 22: 1657.
  • 26
    Quinlan DM, Nelson RJ, Walsh PC. Cavernous nerve grafts restore erectile function in denervated rats. J Urol 1991; 145: 3803.
  • 27
    Carrier S, Zvara P, Nunes L, Kour NW, Rehman J, Lue TF. Regeneration of nitric oxide synthase-containing nerves after cavernous nerve neurotomy in the rat. J Urol 1995; 153: 17227.
  • 28
    Klein LT, Miller MI, Buttyan R, Raffo AJ, Burchard M, Devris G, et al. Apoptosis in the rat penis after penile denervation. J Urol 1997; 158: 62630.
  • 29
    Rosenberg ME, Dvergsten J, Correa-Rotter R. Clusterin: an enigmatic protein recruited by diverse stimuli. J Lab Clin Med 1993; 121: 20514.
  • 30
    Gontero P, Galzerano M, Bartoletti R, Magnani C, Tizzani A, Frea B, et al. New insights into the pathogenesis of penile shortening after radical prostatectomy and the role of postoperative sexual function. J Urol 2007; 178: 6027.
  • 31
    McCullough AR, Fenig D, Robbins D, Brassil D, Goodwin B. A 6-month interim analysis of the effect of nightly intraurethral alprostadil vs. sildenafil on penile morphometrics after nerve spearing radical prostatectomy. American Urological Association Meeting 2007, May 19–24, Anaheim, CA, USA. J Urol 2007; 177 (4 Suppl): Abstract 1173.
  • 32
    Fraiman MC, Lepor H, McCullough AR. Changes in penile morphometrics in men with erectile dysfunction after nerve-sparing radical retropubic prostatectomy. Mol Urol 1999; 3: 10915.
  • 33
    User HM, Hairston JH, Zelner DJ, McKenna KE, McVary KT. Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol 2003; 169: 11759.
  • 34
    Ciancio SJ, Kim ED. Penile fibrotic changes after radical retro-pubic prostatectomy. BJU Int 2000; 85: 1016.
  • 35
    Burnett AL, Becker RE. Immunophilin ligands promote penile neurogenesis and erection recovery after cavernous nerve injury. J Urol 2004; 171: 495500.
  • 36
    Burnett AL, Lue TF. Neuromodulatory therapy to improve erectile function recovery outcomes after pelvic surgery. J Urol 2006; 176: 8827.
  • 37
    Burnett A, McCullough A, Smith J, Montie J, Walsh PC, Steiner J. Neuromodulation to preserve erectile function after radical prostatectomy: results from the GPI1485 neuroimmunophilin ligand clinical trial. American Urological Association Meeting 2007, May 19–24, Anaheim, CA, USA. J Urol 2007; 177 (4 Suppl): Abstract 1162.
  • 38
    Ferrini MG, Davila HH, Kovanecz I, Sanchez SP, Gonzalez-Cadavid NF, Rajfer J. Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat. Urology 2006; 68: 42935.
  • 39
    Rambhatla A, Kovanecz I, Ferrini M, Gonzalez-Cadavid NF, Rajfer J. Rationale for phosphodiesterase 5 inhibitor use post-radical prostatectomy: experimental and clinical review. Int J Impot Res 2007 Aug 2; [Epub ahead of print].
  • 40
    Vignozzi L, Filippi S, Morelli A, Ambrosini S, Luconi M, Vannelli GB, et al. Effect of chronic tadalafil administration on penile hypoxia induces by cavernous neurotomy in the rat. J Sex Med 2006; 3: 41931.
  • 41
    Podlasek CA, Meroz CL, Tang Y, McKenna KE, McVary KT. Regulation of cavernous nerve injury-induced apoptosis by sonic hedgehog. Biol Reprod 2007; 76: 1928.
  • 42
    Podlasek CA, Zelner DJ, Jiang HB, Tang Y, Houston J, McKenna KE, et al. Sonic hedgehog cascade is required for penile postnatal morphogenesis, differentiation, and adult homeostasis. Biol Reprod 2003; 68: 42338.
  • 43
    Podlasek CA, Zelner DJ, Harris JD, Meroz CL, Tang Y, McKenna KE, et al. Altered Sonic hedgehog signaling is associated with morphological abnormalities in the penis of the BB/WOR diabetic rat. Biol Reprod 2003; 69: 81627.
  • 44
    Derby CA, Mohr BA, Goldstein I, Feldman HA, Johannes CB, McKinlay JB. Modifiable risk factors and erectile dysfunction: can lifestyle changes modify risk? Urology 2000; 56: 3026.
  • 45
    Rabbani F, Stapleton AM, Kattan MW, Wheeler TM, Scardino PT. Factors predicting recovery of erections after radical prostatectomy. J Urol 2000; 164: 192934.
  • 46
    McCullough A, Woo K, Telegrafi S, Lepor H. Is sildenafil failure in men after radical retropubic prostatectomy (RRP) due to arterial disease? Penile duplex Doppler findings in 174 men after RRP. Int J Impot Res 2002; 14: 4625.
  • 47
    Gralnek D, Wessells H, Cui H, Dalkin BL. Differences in sexual function and quality of life after nerve sparing and nonnerve sparing radical retropubic prostatectomy. J Urol 2000; 163: 11669; discussion 1169-70.
  • 48
    Kundu SD, Roehl KA, Eggener SE, Antenor JA, Han M, Catalona WJ. Potency, continence and complications in 3,477 consecutive radical retropubic prostatectomies. J Urol 2004; 172 (6 Pt 1): 222731.
  • 49
    Lee SA, Sung KH, Han JH, Han BK, Yu JI, Jeong SJ, et al. Significance of neurovascular bundle formation observed on preoperative magnetic resonance imaging regarding postoperative erectile function after nerve-sparing radical retropubic prostatectomy. Urology 2007; 69: 5104.
  • 50
    Bannowsky A, Schulze H, Van Der Horst C, Stubinger JH, Portillo FJ, Junemann KP. Erectile function after nerve-sparing radical prostatectomy. Nocturnal early erection as a parameter of postoperative organic erectile integrity. Urologe A 2005; 44: 5216.
  • 51
    Kawanishi Y, Lee KS, Kimura K, Kojima K, Yamamoto A, Numata A. Effect of radical retropubic prostatectomy on erectile function, evaluated before and after surgery using colour Doppler ultra-sonography and nocturnal penile tumescence monitoring. BJU Int 2001; 88: 2447.
  • 52
    Lerner SE, Richards SL, Benet AE, Kahan NZ, Fleischmann JD, Melman A. Detailed evaluation of sexual function after radical prostatectomy: is patient satisfaction correlated with the quality of erections?. Prog Urol 1996; 6: 5527. French.
  • 53
    Fraiman M, Lepor H, McCullough A. Nocturnal penile tumescence activity in 81 patients presenting with erectile dysfunction after nerve sparing radical prostatectomy. American Urological Association 94th Annual Meeting. Dallas, TX, USA. May 1–6, 1999. J Urol 1999; 161: 179 (Abstract).
  • 54
    Levine LM, McCullough AR, Padma-Nathan H. Longitudinal randomized placebo controlled study of the return of nocturnal erections after nerve sparing radical prostatectomy in men treated with nightly sildenafil citrate. American Urological Association Annual Meeting 2004. May 8–13, San Francisco, CA, USA. J Urol 1004; 171: 231 (Abstract 875).
  • 55
    Padma-Nathan H, McCullough AR, Giuliano F, Toler SM, Wohlhuter C, Shpilsky AB. Postoperative nightly administration of sildenafil citrate significantly improves the return of normal spontaneous erectile function after bilateral nerve-sparing radical prostatectomy. American Urological Association Annual Meeting 2003. Chicago, IL, USA. April 26-May 1. J Urol 2003; 169 (4 Suppl): Abstract 1402.
  • 56
    Leungwattanakij S, Bivalacqua TJ, Usta MF, Yang DY, Hyun JS, Champion HC, et al. Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum. J Androl 2003; 24: 23945.
  • 57
    Moreland RB. Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence. Int J Impot Res 1998; 10: 11320.
  • 58
    Hu WL, Hu LQ, Song J, Li SW, Zheng XM, Cheng B, Tian BC. Fibrosis of corpus cavernosum in animals following cavernous nerve ablation. Asian J Androl 2004; 6: 1116.
  • 59
    Moreland RB, Traish A, McMillin MA, Smith B, Goldstein I, Saenz de Tejada I. PGE1 suppresses the induction of collagen synthesis by transforming growth factor-beta 1 in human corpus cavernosum smooth muscle. J Urol 1995; 153 (3 Pt 1): 82634.
  • 60
    Kim NN, Kim JJ, Hypolite J, Garcia-Diaz JF, Broderick GA, Tornheim K, et al. Altered contractility of rabbit penile corpus cavernosum smooth muscle by hypoxia. J Urol 1996; 155: 7728.
  • 61
    Kim N, Vardi Y, Padma-Nathan H, Daley J, Goldstein I, Saenz de Tejada I, et al. Oxygen tension regulates the nitric oxide pathway. Physiological role in penile erection. J Clin Invest 1993; 91: 43742.
  • 62
    Padmanaban P, McCullough AR. The relationship between post radical retropubic prostatectomy (RRP) erectile dysfunction (ED) and corporal oxygen saturation (StO2) in the flaccid penis. J Androl 2007; 28: 2238.
  • 63
    Schwartz EJ, Wong P, Graydon RJ. Sildenafil preserves intra-corporeal smooth muscle after radical retropubic prostatectomy. J Urol 2004; 171 (2 Pt 1): 7714.
  • 64
    Montorsi F, Guazzoni G, Strambi LF, Da Pozzo LF, Nava L, Barbieri L, et al. Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: results of a prospective, randomized trial. J Urol 1997; 158: 140810.
  • 65
    Bosshardt RJ, Farwerk R, Sikora R, Sohn M, Jakse G. Objective measurement of the effectiveness, therapeutic success and dynamic mechanisms of the vacuum device. Br J Urol 1995; 75: 78691.
  • 66
    Broderick GA, McGahan JP, Stone AR, White RD. The hemodynamics of vacuum constriction erections: assessment by color Doppler ultrasound. J Urol 1992; 147: 5761.
  • 67
    Diederichs W, Stief CG, Benard F, Bosch R, Lue TF, Tanagho EA. The sympathetic role as an antagonist of erection. Urol Res 1991; 19: 1236.
  • 68
    Raina R, Agarwal A, Ausmundson S, Lakin M, Nandipati KC, Montague DK, et al. Early use of vacuum constriction device following radical prostatectomy facilitates early sexual activity and potentially earlier return of erectile function. Int J Impot Res 2006; 18: 7781.
  • 69
    Moon DG, Lee DS, Kim JJ. Altered contractile response of penis under hypoxia with metabolic acidosis. Int J Impot Res 1999; 11: 26571.
  • 70
    Eardley I, Ellis P, Boolell M, Wulff M. Onset and duration of action of sildenafil for the treatment of erectile dysfunction. Br J Clin Pharmacol 2002; 53 (Suppl 1): 61S65S.
  • 71
    Nandipati K, Raina R, Agarwal A, Zippe CD. Early combination therapy: intracavernosal injections and sildenafil following radical prostatectomy increases sexual activity and the return of natural erections. Int J Impot Res 2006; 18: 44651.
  • 72
    Mulhall J, Land S, Parker M, Waters WB, Flanigan RC. The use of an erectogenic pharmacotherapy regimen following radical prostatectomy improves recovery of spontaneous erectile function. J Sex Med 2005; 2: 53240; discussion 540-2.
  • 73
    Gontero P, Fontana F, Bagnasacco A, Panella M, Kocjancic E, Pretti G, et al. Is there an optimal time for intracavernous prostaglandin El rehabilitation following nonnerve sparing radical prostatectomy? Results from a hemodynamic prospective study. J Urol 2003; 169: 21669.
  • 74
    Costabile RA, Spevak M, Fishman IJ, Govier FE, Hellstrom WJ, Shabsigh R, et al. Efficacy and safety of transurethral alprostadil in patients with erectile dysfunction following radical prostatectomy. J Urol 1998; 160: 13258.
  • 75
    Raina R, Agarwal A, Ausmundson S, Mansour D, Zippe CD. Long-term efficacy and compliance of MUSE for erectile dysfunction following radical prostatectomy: SHIM (IIEF-5) analysis. Int J Impot Res 2005; 17: 8690.
  • 76
    Raina R, Agarwal A, Nandipati KC, Zippe CD. Interim analysis of the early use of MUSE following radical prostatectomy (RP) to facilitate early sexual activity and return of spontaneous erectile function. American Urological Association Meeting 2005, May 21–26, San Antonio, TX, USA. J Urol 2005; 173 (4 Suppl): Abstract 737.
  • 77
    Snider WD, Zhou FQ, Zhong J, Markus A. Signaling the pathway to regeneration. Neuron 2002; 35: 136.
  • 78
    McCoy GB, Barry JM, Lieberman SF, Pearse HD, Wicklund R. Treatment of obliterated membranous and bulbous urethras by direct vision internal urethrotomy. J Trauma 1987; 27: 8836.
  • 79
    Chierzi S, Ratto GM, Verma P, Fawcett JW. The ability of axons to regenerate their growth cones depends on axonal type and age, and is regulated by calcium, cAMP and ERK. Eur J Neurosci 2005; 21: 205162.
  • 80
    Jiang F, Yang L, Cai X, Cyriac J, Shechter I, Wang Z. Farnesyl diphosphate synthase is abundantly expressed and regulated by androgen in rat prostatic epithelial cells. J Steroid Biochem Mol Biol 2001; 78: 12330.
  • 81
    Kogawa T, Yanagiya H, Takashima T, Higashino I, Kudo T, Suzuki T, et al. Clinical evaluation of the long-term treatment with chlormadinone acetate in patients with benign prostatic hypertrophy. Hinyokika Kiyo 1993; 39: 2817.
  • 82
    Padmanaban P, McCullough AR. The effect of prostaglandin E-1 (PGE-1) urethral suppository (MUSE™) and injections on corporal oxygen saturation (StO2) in men with erectile dysfunction (ED). Amercian Society of Andrology Meeting 2006, April 8–11, Chicago IL, USA. J Androl 2006; 27: Abstract.
  • 83
    Lowentritt BH, Scardino PT, Miles BJ, Orejuela FJ, Schatte EC, Slawin KM, et al. Sildenafil citrate after radical retropubic prostatectomy. J Urol 1999; 162: 16147.
  • 84
    Brock G, Nehra A, Lipshultz LI, Karlin GS, Gleave M, Seger M, et al. Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical retropubic prostatectomy. J Urol 2003; 170 (4 Pt 1): 127883.
  • 85
    Montorsi F, Nathan HP, McCullough A, Brock GB, Broderick G, Ahuja S, et al. Tadalafil in the treatment of erectile dysfunction following bilateral nerve sparing radical retropubic prostatectomy: a randomized, double-blind, placebo controlled trial. J Urol 2004; 172: 103641. Erratum in: J Urol 2005; 173: 664.
  • 86
    Hong EK, Lepor H, McCullough AR. Time dependent patient satisfaction with sildenafil for erectile dysfunction (ED) after nerve-sparing radical retropubic prostatectomy (RRP). Int J Impot Res 1999; 11 (Suppl 1): S1522.
  • 87
    Walsh PC. Patient-reported urinary continence and sexual function after anatomic radical prostatectomy. J Urol 2000; 164:242.
  • 88
    Gontero P, Kirby R. Proerectile pharmacological prophylaxis following nerve-sparing radical prostatectomy (NSRP). Prostate Cancer Prostatic Dis 2004; 7: 2236.
  • 89
    Montorsi F, Maga T, Strambi LF, Salonia A, Barbieri L, Scattoni V, et al. Sildenafil taken at bedtime significantly increases nocturnal erections: results of a placebo-controlled study. Urology 2000; 56: 90611.
  • 90
    Katz SD. Potential role of type 5 phosphodiesterase inhibition in the treatment of congestive heart failure. Congest Heart Fail 2003; 9: 915.
  • 91
    Katz SD, Balidemaj K, Homma S, Wu H, Wang J, Maybaum S. Acute type 5 phosphodiesterase inhibition with sildenafil enhances flow-mediated vasodilation in patients with chronic heart failure. J Am Coll Cardiol 2000; 36: 84551.
  • 92
    Desouza C, Parulkar A, Lumpkin D, Akers D, Fonseca VA. Acute and prolonged effects of sildenafil on brachial artery flow-mediated dilatation in type 2 diabetes. Diabetes Care 2002; 25: 13369.
  • 93
    Zhang R, Wang Y, Zhang L, Zhang Z, Tsang W, Lu M, et al. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke 2002; 33: 267580.
  • 94
    Parsons JK, Marschke P, Maples P, Walsh PC. Effect of methylprednisolone on return of sexual function after nerve-sparing radical retropubic prostatectomy. Urology 2004; 64: 98790.
  • 95
    Deliveliotis C, Delis A, Papatsoris A, Antoniou N, Varkarakis IM. Local steroid application during nerve-sparing radical retropubic prostatectomy. BJU Int 2005; 96: 5335.