Reexploring the Possible Roles of Some Genes Associated with Nasopharyngeal Carcinoma Using Microarray-based Detection

  1. Wei-Yi FANG1,2,†,
  2. Teng-Fei LIU1,†,
  3. Wei-Bing XIE2,
  4. Xu-Yu YANG1,
  5. Shuang WANG2,
  6. Cai-Ping REN1,
  7. Xin DENG2,
  8. Qiu-Zhen LIU2,
  9. Zhong-Xi HUANG2,
  10. Xin LI2,
  11. Yan-Qing DING2,
  12. Kai-Tai YAO1,2,*

Article first published online: 11 AUG 2005

DOI: 10.1111/j.1745-7270.2005.00074.x

Issue

Acta Biochimica et Biophysica Sinica

Acta Biochimica et Biophysica Sinica

Volume 37, Issue 8, pages 541–546, August 2005

Additional Information

How to Cite

FANG, W.-Y., LIU, T.-F., XIE, W.-B., YANG, X.-Y., WANG, S., REN, C.-P., DENG, X., LIU, Q.-Z., HUANG, Z.-X., LI, X., DING, Y.-Q. and YAO, K.-T. (2005), Reexploring the Possible Roles of Some Genes Associated with Nasopharyngeal Carcinoma Using Microarray-based Detection. Acta Biochimica et Biophysica Sinica, 37: 541–546. doi: 10.1111/j.1745-7270.2005.00074.x

Author Information

  1. 1

    Cancer Research Institute, Xiangya Medical School, Central South University, Changsha 410078, China;

  2. 2

    Cancer Research Institute, Nanfang Medical University, Guangzhou 510515, China

  1. †

    These authors contributed equally to this work

* *Tel, 86-731-4805451; Fax, 86-731-4360094; E-mail, ktyao@fimmu.com

Publication History

  1. Issue published online: 11 AUG 2005
  2. Article first published online: 11 AUG 2005
  3. Received: March 8, 2005 Accepted: May 11, 2005

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Keywords:

  • nasopharynx (NP);
  • nasopharyngeal carcinoma (NPC);
  • MILANO;
  • differentially expressed gene

Abstract In gene expression profiling, nasopharyngeal carcinoma (NPC) 5-8F cells differ from 6-10B cells in terms of their high tumorigenicity and metastatic ability. Differentially expressed genes from the two cell types were analyzed by combining with MILANO (the automatic custom annotation of microarray results which is based on all the available published work in PubMed). The results showed that five genes, including CTSD, P63, CSE1L, BPAG1 and EGR1, have been studied or mentioned in published work on NPC. Subsequently, we revaluated the roles of these genes in the pathogenesis of NPC by combining the data of gene chips from NPCs versus NPs and pooled cells from 5-8F, 6-10B and CNE2 versus NPs. The results suggested that the roles of BPAG1 and EGR1 are possibly different from those reported in previous NPC studies. These five genes are likely to be involved in the proliferation, apoptosis, invasion and metastasis of NPC. A reexploration of the genes will further define their roles in the pathogenesis of NPC.

Edited by Yao LI

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