Structure and Function of the NS1 Protein of Influenza A Virus

  1. Dongzi LIN1,
  2. Jingfang LAN2,
  3. Zhizhen ZHANG1,*

Article first published online: 16 MAR 2007

DOI: 10.1111/j.1745-7270.2007.00263.x

Issue

Acta Biochimica et Biophysica Sinica

Acta Biochimica et Biophysica Sinica

Volume 39, Issue 3, pages 155–162, March 2007

Additional Information

How to Cite

LIN, D., LAN, J. and ZHANG, Z. (2007), Structure and Function of the NS1 Protein of Influenza A Virus. Acta Biochimica et Biophysica Sinica, 39: 155–162. doi: 10.1111/j.1745-7270.2007.00263.x

Author Information

  1. 1

    Department of Biochemistry and Molecular Biology, Guangdong Medical College, Zhanjiang 524023, China

  2. 2

    Department of Clinical Laboratory, Hejin People's Hospital, Hejin 043300, China

*Correspondence: Zhizhen ZHANG,

*Correspondence: *Corresponding author: Tel, 86-759-2388582; Fax, 86-759-2284104; E-mail, zzz200cn@yahoo.com.cn

Publication History

  1. Issue published online: 16 MAR 2007
  2. Article first published online: 16 MAR 2007
  3. Received: October 14, 2006 Accepted: December 12, 2006

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

Get PDF (1997K)

Keywords:

  • influenza A virus;
  • NS1A protein;
  • RNA-binding domain;
  • effector domain;
  • dimer;
  • resistance;
  • antiviral response

Abstract

The avian influenza A virus currently prevailing in Asia causes fatal pneumonia and multiple organ failure in birds and humans. Despite intensive research, understanding of the characteristics of influenza A virus that determine its virulence is incomplete. NS1A protein, a non-structural protein of influenza A virus, was reported to contribute to its pathogenicity and virulence. NS1A protein is a multifunctional protein that plays a significant role in resisting the host antiviral response during the influenza infection. This review briefly outlines the current knowledge on the structure and function of the NS1A protein.

Get PDF (1997K)