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Wnt signaling: the good and the bad
Article first published online: 16 JUL 2008
DOI: 10.1111/j.1745-7270.2008.00440.x
© 2008 Institute of Biochemistry and Cell Biology, SIBS, CAS
Additional Information
How to Cite
Chen, X., Yang, J., Evans, P. M. and Liu, C. (2008), Wnt signaling: the good and the bad. Acta Biochimica et Biophysica Sinica, 40: 577–594. doi: 10.1111/j.1745-7270.2008.00440.x
Publication History
- Issue published online: 16 JUL 2008
- Article first published online: 16 JUL 2008
- Received: April 24, 2008 Accepted: May 16, 2008
- Abstract
- References
- Cited By
Keywords:
- Wnt signaling;
- β-catenin;
- cancer;
- stem cell
Since the first Wnt gene was identified in 1982, the functions and mechanisms of Wnt signaling have been extensively studied. Wnt signaling is conserved from invertebrates to vertebrates and regulates early embryonic development as well as the homeostasis of adult tissues. In addition, both embryonic stem cells and adult stem cells are regulated by Wnt signaling. Deregulation of Wnt signaling is associated with many human diseases, particularly cancers. In this review, we will discuss in detail the functions of many components involved in the Wnt signal transduction pathway. Then, we will explore what is known about the role of Wnt signaling in stem cells and cancers.