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New insights of epithelial-mesenchymal transition in cancer metastasis
Article first published online: 16 JUL 2008
DOI: 10.1111/j.1745-7270.2008.00443.x
© 2008 Institute of Biochemistry and Cell Biology, SIBS, CAS
Additional Information
How to Cite
Wu, Y. and Zhou, B. P. (2008), New insights of epithelial-mesenchymal transition in cancer metastasis. Acta Biochimica et Biophysica Sinica, 40: 643–650. doi: 10.1111/j.1745-7270.2008.00443.x
Publication History
- Issue published online: 16 JUL 2008
- Article first published online: 16 JUL 2008
- Received: May 29, 2008 Accepted: June 9, 2008
- Abstract
- References
- Cited By
Keywords:
- epithelial-mesenchymal transition;
- metastasis;
- Snail;
- Twist;
- signal transduction
Epithelial-mesenchymal transition (EMT) is a key step during embryonic morphogenesis, heart development, chronic degenerative fibrosis, and cancer metastasis. Several distinct traits have been conveyed by EMT, including cell motility, invasiveness, resistance to apoptosis, and some properties of stem cells. Many signal pathways have contributed to the induction of EMT, such as transforming growth factor-β, Wnt, Hedgehog, Notch, and nuclear factor-κB. Over the last few years, increasing evidence has shown that EMT plays an essential role in tumor progression and metastasis. Understanding the molecular mechanism of EMT has a great effect in unraveling the metastatic cascade and may lead to novel interventions for metastatic disease.