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Epidermal growth factor induces changes of interaction between epidermal growth factor receptor and actin in intact cells
Article first published online: 12 AUG 2008
DOI: 10.1111/j.1745-7270.2008.00447.x
© 2008 Institute of Biochemistry and Cell Biology, SIBS, CAS
Additional Information
How to Cite
Song, W., Xuan, H. and Lin, Q. (2008), Epidermal growth factor induces changes of interaction between epidermal growth factor receptor and actin in intact cells. Acta Biochimica et Biophysica Sinica, 40: 754–760. doi: 10.1111/j.1745-7270.2008.00447.x
Publication History
- Issue published online: 12 AUG 2008
- Article first published online: 12 AUG 2008
- Received: April 20, 2008 Accepted: May 28, 2008
- Abstract
- References
- Cited By
Keywords:
- epidermal growth factor receptor;
- actin;
- fluorescence resonance energy transfer;
- interaction
The epidermal growth factor receptor (EGFR) is a cyto-skeleton-binding protein. Although purified EGFR can interact with acting in vitro and normally at least 10% of EGFR exist in the insoluble cytoskeleton fraction of A431 cells, interaction of cytosolic EGFR with actin can only be visualized by fluorescence resonance energy transfer when epidermal growth factor presents in the cell medium. Results indicate that the correct orientation between EGFR and actin is important in the signal transduction process.