The spatiotemporal expression changes of 16 epididymis-specific genes induced by testosterone, heat, and combination treatment in cynomolgus monkey

  1. Xiangqi Li1,2,†,
  2. Qiang Liu2,†,
  3. Shigui Liu1,
  4. Xuesen Zhang4,
  5. Yixun Liu4,
  6. Yonglian Zhang2,3,*

Article first published online: 12 AUG 2008

DOI: 10.1111/j.1745-7270.2008.00451.x

Issue

Acta Biochimica et Biophysica Sinica

Acta Biochimica et Biophysica Sinica

Volume 40, Issue 8, pages 721–728, August 2008

Additional Information

How to Cite

Li, X., Liu, Q., Liu, S., Zhang, X., Liu, Y. and Zhang, Y. (2008), The spatiotemporal expression changes of 16 epididymis-specific genes induced by testosterone, heat, and combination treatment in cynomolgus monkey. Acta Biochimica et Biophysica Sinica, 40: 721–728. doi: 10.1111/j.1745-7270.2008.00451.x

Author Information

  1. 1

    College of Life Science, Sichuan University, Chengdu 610064, China

  2. 2

    Shanghai Key Laboratory for Molecular Andrology, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

  3. 3

    Shanghai Institute of Planned Parenthood Research, Shanghai 200032, China

  4. 4

    State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China

  1. †

    These authors contributed equally to this work

* *Corresponding author: Tel/Fax, 86-21-54921163; E-mail, ylzhang@sibs.ac.cn

Publication History

  1. Issue published online: 12 AUG 2008
  2. Article first published online: 12 AUG 2008
  3. Received: April 10, 2008 Accepted: April 25, 2008

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Keywords:

  • epididymis;
  • gene expression;
  • androgen;
  • temperature;
  • infertility model

The experimental infertility model of treatments involving testicular warming, testosterone implant, and a combination of the two was developed to confirm a synergistic action induced by the combination treatment on germ cell apoptosis in cynomolgus monkey testis. Using this model, the spatio-temporal expression changes of 16 reported or novel genes in epididymis were investigated to examine the treatment's effect on epididymal genes. It was demonstrated that these region-specific genes, some of which were not regionally fixed, changed greatly with these treatments. The expression levels of these epididymal genes fluctuated, and the expression of most of the genes returned to nearly normal level at the end of treatments. Moreover, the expression changes resulting from the combination treatment were not more significant than those resulting from the single treatment. This suggests that the combination treatment has an antagonistic action on the expression of epididymal genes and that its effect is not as adverse on epididymis as that of the two single treatments.

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