Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques

  1. Dongyun Ouyang1,†,
  2. Lihui Xu2,†,
  3. Zhengxi Dai3,4,
  4. Huanjing Shi1,
  5. Gaohong Zhang3,
  6. Yongtang Zheng3,*,
  7. Xianhui He1,*

Article first published online: 1 DEC 2008

DOI: 10.1111/j.1745-7270.2008.00474.x

Issue

Acta Biochimica et Biophysica Sinica

Acta Biochimica et Biophysica Sinica

Volume 40, Issue 11, pages 919–927, November 2008

Additional Information

How to Cite

Ouyang, D., Xu, L., Dai, Z., Shi, H., Zhang, G., Zheng, Y. and He, X. (2008), Identification of major histocompatibility complex class I alleles in Chinese rhesus macaques. Acta Biochimica et Biophysica Sinica, 40: 919–927. doi: 10.1111/j.1745-7270.2008.00474.x

Author Information

  1. 1

    Institute of Tissue Transplantation and Immunology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China

  2. 2

    Institute of Bioengineering, College of Life Science and Technology, Jinan University, Guangzhou 510632, China

  3. 3

    Laboratory of Molecular Immunopharmacology, Key Laboratory of Animal Models and Human Diseases Mechanisms, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China

  4. 4

    Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

  1. †

    These authors contributed equally to this work

* *Corresponding authors: Prof. Xianhui He: Tel, 86–20–85220679; Fax, 86–20–85221337; Email, thexh@jnu.edu.cn Prof. Yongtang Zheng: Tel/Fax, 86–871–5195684; E-mail, zhengyt@mail.kiz.ac.cn

Publication History

  1. Issue published online: 1 DEC 2008
  2. Article first published online: 1 DEC 2008
  3. Received: April 24, 2008 Accepted: September 12, 2008

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Keywords:

  • Mamu-A;
  • Mamu-B;
  • MHC class I;
  • rhesus macaque

Major histocompatibility complex (MHC) class I information is vital for understanding variance of immune responses in HIV vaccination and biomedical models. In this study, 9 Mamu-A and 13 Mamu-B alleles were identified from the cDNA products of 10 Chinese-origin rhesus macaques. Except for two alleles that had been reported by others, eight were novel and twelve extended the partial sequences that are available in GenBank. The additional information of MHC class I antigens might be beneficial to the availability of Chinese macaques in human disease studies. Furthermore, the polymorphism of leading peptides and the natural killer receptor recognition motifs in α1 domain both implies that Mamu-A and Mamu-B molecules might play key roles in innate immune responses of natural killer cells.

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