Inhibition of Lux quorum-sensing system by synthetic N-acyl-L-homoserine lactone analogous

  1. Wenzhao Wang1,2,
  2. Tomohiro Morohoshi1,*,
  3. Tsukasa Ikeda1,
  4. Liang Chen2,*

Article first published online: 16 DEC 2008

DOI: 10.1111/j.1745-7270.2008.00490.x

Issue

Acta Biochimica et Biophysica Sinica

Acta Biochimica et Biophysica Sinica

Volume 40, Issue 12, pages 1023–1028, December 2008

Additional Information

How to Cite

Wang, W., Morohoshi, T., Ikeda, T. and Chen, L. (2008), Inhibition of Lux quorum-sensing system by synthetic N-acyl-L-homoserine lactone analogous. Acta Biochimica et Biophysica Sinica, 40: 1023–1028. doi: 10.1111/j.1745-7270.2008.00490.x

Author Information

  1. 1

    Department of Material and Environmental Chemistry, Utsunomiya University, Utsunomiya, Tochigi 321-8585, Japan

  2. 2

    College of Environmental Science and Engineering, Dong Hua University, Shanghai 201620, China

* *Corresponding authors: Tomohiro Morohoshi: Tel, 81-28-6896176; Fax, 81-28-6896176; E-mail, morohosi@cc.utsunomiya-u.ac.jp Liang Chen: Tel, 86-21-67792548; E-mail, chliang@dhu.edu.cn

Publication History

  1. Issue published online: 16 DEC 2008
  2. Article first published online: 16 DEC 2008
  3. Received: September 1, 2008 Accepted: October 13, 2008

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Keywords:

  • quorum sensing;
  • inhibitor;
  • Vibrio fischeri;
  • Lux

In the present study, we investigated the inhibition of the Lux quorum-sensing system by N-acyl cyclopentylamine (Cn-CPA). The Lux quorum-sensing system regulates luminescence gene expression in Vibrio fischeri. We have already reported on the synthesis of Cn-CPA and their abilities as inhibitors of the quorum-sensing systems in Pseudomonas aeruginosa and Serratia marcescens. In the case of Pseudomonas aeruginosa (Las and Rhl quorum-sensing system) and Serratia marcescens (Spn quorum-sensing system), specific Cn-CPA with a particular acyl chain length showed the strongest inhibitory effect. In the case of the Lux quorum-sensing system, it was found that several kinds of Cn-CPA with a range from C5 to C10 showed similar strong inhibitory effects. Moreover, the inhibitory effect of Cn-CPA on the Lux quorum-sensing system was stronger than that of halogenated furanone, a natural quorum-sensing inhibitor.

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