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Current understanding and management of dilated cardiomyopathy in Duchenne and Becker muscular dystrophy
Article first published online: 1 MAY 2009
© 2009 The Author(s) Journal compilation © 2009 American Academy of Nurse Practitioners
Journal of the American Academy of Nurse Practitioners
Volume 21, Issue 5, pages 241–249, May 2009
How to Cite
Kaspar, R. W., Allen, H. D. and Montanaro, F. (2009), Current understanding and management of dilated cardiomyopathy in Duchenne and Becker muscular dystrophy. Journal of the American Academy of Nurse Practitioners, 21: 241–249. doi: 10.1111/j.1745-7599.2009.00404.x
- Issue published online: 1 MAY 2009
- Article first published online: 1 MAY 2009
- Received: December 2007;accepted: March 2008
- muscular dystrophy;
Purpose: To review the current understanding of the pathophysiology of dilated cardiomyopathy (DCM) in patients with Duchenne and Becker muscular dystrophies, assessment of cardiac dysfunction for these patients, and the recommended pharmacological treatment options and ongoing research directions.
Data sources: Reviews and original research articles from scholarly journals and books.
Conclusions: Duchenne and Becker muscular dystrophies are debilitating neuromuscular disorders, both caused by mutations in the dystrophin gene. Most patients develop DCM as part of the disease course; in fact, DCM is the leading cause of death among these patients. Cardiac surveillance, including routine monitoring of electrocardiograms, echocardiograms, and appropriate blood biomarkers, may detect early DCM development. Although previous studies have shown that early administration of cardiac medications may delay the development of DCM, current standard of care does not emphasize cardiac surveillance and timely treatment. This, in turn, limits clinicians, including advanced practice nurses, to be optimally engaged in providing the most aggressive and proactive patient care.
Implications for practice: Implementing a routine cardiac assessment and timely pharmacological treatment in primary or specialty care settings is highlighted as an important step to optimize cardiac health among patients with Duchenne and Becker muscular dystrophies.