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Oral magnesium supplementation in adults with coronary heart disease or coronary heart disease risk
Article first published online: 1 DEC 2009
DOI: 10.1111/j.1745-7599.2009.00460.x
© 2009 The Author(s). Journal compilation © 2009 American Academy of Nurse Practitioners
Issue
Journal of the American Academy of Nurse Practitioners
Volume 21, Issue 12, pages 651–657, December 2009
Additional Information
How to Cite
Mathers, T. W. and Beckstrand, R. L. (2009), Oral magnesium supplementation in adults with coronary heart disease or coronary heart disease risk. Journal of the American Academy of Nurse Practitioners, 21: 651–657. doi: 10.1111/j.1745-7599.2009.00460.x
Publication History
- Issue published online: 1 DEC 2009
- Article first published online: 1 DEC 2009
- Received: May 2008; accepted: October 2008
- Abstract
- Article
- References
- Cited By
Keywords:
- Coronary heart disease;
- coronary heart disease risk;
- magnesium supplementation
Abstract
Purpose: To review randomized control clinical trial (RCT) literature and prospective studies for the safety and efficacy of magnesium supplements in patients with coronary heart disease (CHD) or with CHD risk.
Data sources: Databases were searched using the keywords: magnesium, heart disease, endothelium, prevention, treatment, therapy, level, and supplement.
Conclusions: There were no reports of adverse effects from magnesium supplementation in any of the studies. Subjects reporting lower dietary magnesium intake had significantly lower serum magnesium concentrations than those reporting higher dietary magnesium intake and, in some cases, had a significantly higher frequency of supraventricular beats. There was a modest relationship between dietary magnesium intake and a reduced risk of CHD in male subjects; however, there was no noted decrease in the development of CHD disease in women who had high magnesium intake.
Implications for practice: Magnesium is vital for many functions in the body and magnesium supplementation is safe. There is a possible association between a modestly lower risk of CHD in men and increased magnesium intake; therefore, it is reasonable to encourage diets high in magnesium as a potential means to lower the risk of CHD.