Disclosures The author of this article has not received any editorial services or financial support from any pharmaceutical company or establishment.
A brief review of pharmacotherapeutic treatment options in smoking cessation: bupropion versus varenicline
Version of Record online: 3 SEP 2010
©2010 The Author Journal compilation ©2010 American Academy of Nurse Practitioners
Journal of the American Academy of Nurse Practitioners
Volume 22, Issue 10, pages 557–563, October 2010
How to Cite
Johnson, T. S. (2010), A brief review of pharmacotherapeutic treatment options in smoking cessation: bupropion versus varenicline. Journal of the American Academy of Nurse Practitioners, 22: 557–563. doi: 10.1111/j.1745-7599.2010.00550.x
- Issue online: 11 OCT 2010
- Version of Record online: 3 SEP 2010
- Received: March 2009;accepted: May 2009
- Smoking behavior;
- smoking cessation;
- behavior modification;
- advanced practice nurse (APN);
- nicotine addiction
Abstract Purpose: The purpose of this article is to compare the efficacy of two prominent medications utilized in smoking cessation: bupropion and varenicline.
Data sources: Comprehensive review of the literature on bupropion and varenicline including randomized control trials, government reports, journal reviews, and pharmaceutical inserts.
Conclusions: In all studies comparing varenicline to bupropion and/or placebo, varenicline yielded a greater cessation rate at both 3 and 12 months. Additionally, varenicline 1 mg indicated an increased potential for long-term cessation success when compared with varenicline 0.5 mg. When compared with only placebo, bupropion demonstrated a higher efficacy for cessation both at 3 and 12 months.
Implications for practice: Only 6% of the 20 million smokers who attempt to quit will succeed in long term. Clinicians must assess their patient's willingness to quit and educate them about cessation options. Knowing the efficacy of various treatment options for patients will potentially increase their success at quitting smoking. Understanding the treatment options available, allows for clinicians to provide the best possible method for smoking cessation for their patient population.