You have free access to this content

Convenient and Efficient Preparations of Azodye-Labeled Peptides

  1. Alan R. Katritzky*,
  2. Qi-Yin Chen,
  3. Srinivasa R. Tala

Article first published online: 12 MAY 2009

DOI: 10.1111/j.1747-0285.2009.00813.x

Issue

Chemical Biology & Drug Design

Chemical Biology & Drug Design

Volume 73, Issue 6, pages 611–617, June 2009

Additional Information

How to Cite

Katritzky, A. R., Chen, Q.-Y. and Tala, S. R. (2009), Convenient and Efficient Preparations of Azodye-Labeled Peptides. Chemical Biology & Drug Design, 73: 611–617. doi: 10.1111/j.1747-0285.2009.00813.x

Author Information

  1. Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA

* *Alan R. Katritzky, katritzky@chem.ufl.edu

Publication History

  1. Issue published online: 12 MAY 2009
  2. Article first published online: 12 MAY 2009
  3. Received 25 November 2008, revised 20 March 2009 and accepted for publication 20 March 2009

SEARCH

SEARCH BY CITATION

ARTICLE TOOLS

View Full Article with Supporting Information (HTML) Get PDF (147K)

Keywords:

  • azodye;
  • benzotriazole methodology;
  • N-protected(α-aminoacyl)benzotriazole;
  • photoisomerization;
  • small peptides

N-(4-Arylazobenzoyl)-1H-benzotriazoles 15a, 15b react with dipeptides 12a–d, (12d+12d′) and tripeptides 14a, 14b to give azodye labeled-dipeptides (16a–e), (16d+16d′), (16e+16e′) and -tripeptides 16f, 16g in high yields (73–93%) with retention of chirality.

View Full Article with Supporting Information (HTML) Get PDF (147K)