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Figure S1. Ligands featured in the available X-ray structures of c-Met complexes. On the right: X-ray PDB code, ligand name (if any), resolution and release date of structure, origin, patent(s) for compound (if any).

Figure S2. Alignment of the human c-Met kinase domain sequence with those of other tyrosine kinases whose ATP-complexed structure is known.

Figure S3. Overview of the X-ray resolved c-Met complexes, their secondary structures, and their defects subsequently corrected during the modeling process described in the paper.

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