• 1
    Lin S.J., Defossez P.A., Guarente L. (2000) Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science;289:21262128.
  • 2
    Cohen H.Y., Miller C., Bitterman K.J., Wall N.R., Hekking B., Kessler B., Howitz K.T., Gorospe M., De Cabo R., Sinclair D.A. (2004) Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science;305:390392.
  • 3
    Picard F., Kurtev M., Chung N., Topark-Ngarm A., Senawong T., Machado De Oliveira R., Leid M., McBurney M.W., Guarente L. (2004) Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature;429:771776.
  • 4
    Rodgers J.T., Lerin C., Haas W., Gygi S.P., Spiegelman B.M., Puigserver P. (2005) Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1. Nature;434:113118.
  • 5
    Yang T., Fu M., Pestell R., Sauve A.A. (2006) SIRT1 and endocrine signaling. Trends Endocrinol Metab;17:186191.
  • 6
    Howitz K.T., Bitterman K.J., Cohen H.Y., Lamming D.W., Lavu S., Wood J.G., Zipkin R.E., Chung P., Kisielewski A., Zhang L.L., Scherer B., Sinclair D.A. (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature;425:191196.
  • 7
    Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V. et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature;444:337342.
  • 8
    Lagouge M., Argmann C., Gerhart-Hines Z., Meziane H., Lerin C., Daussin F., Messadeq N., Milne J., Lambert P., Elliott P., Geny B., Laakso M., Puigserver P., Auwerx J. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha. Cell;127:11091122.
  • 9
    Borra M.T., Smith B.C., Denu J.M. (2005) Mechanism of human SIRT1 activation by resveratrol. J Biol Chem;280:1718717195.
  • 10
    Kaeberlein M., McDonagh T., Heltweg B., Hixon J., Westman E.A., Caldwell S.D., Napper A., Curtis R., DiStefano P.S., Fields S., Bedalov A., Kennedy B.K. (2005) Substrate-specific activation of sirtuins by resveratrol. J Biol Chem;280:1703817045.
  • 11
    Zhang J. (2006) Resveratrol inhibits insulin responses in a SirT1-independent pathway. Biochem J;397:519527.
  • 12
    Milne J.C., Lambert P.D., Schenk S., Carney D.P., Smith J.J., Gagne D.J., Jin L. et al. (2007) Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature;450:712716.
  • 13
    Liu Y., Gerber R., Wu J., Tsuruda T., McCarter J.D. (2008) High-throughput assays for sirtuin enzymes: a microfluidic mobility shift assay and a bioluminescence assay. Anal Biochem;378:5359.
  • 14
    Cheng H.L., Mostoslavsky R., Saito S., Manis J.P., Gu Y., Patel P., Bronson R., Appella E., Alt F.W., Chua K.F. (2003) Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA;100:1079410799.
  • 15
    Lerin C., Rodgers J.T., Kalume D.E., Kim S.H., Pandey A., Puigserver P. (2006) GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC-1alpha. Cell Metab;3:429438.
  • 16
    Cantó C., Gerhart-Hines Z., Feige J.N., Lagouge M., Noriega L., Milne J.C., Elliott P.J., Puigserver P., Auwerx J. (2009) AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature;458:10561060.
  • 17
    Dasgupta B., Milbrandt J. (2007) Resveratrol stimulates AMP kinase activity in neurons. Proc Natl Acad Sci USA;104:72177222.
  • 18
    Park C.E., Kim M.J., Lee J.H., Min B.I., Bae H., Choe W., Kim S.S., Ha J. (2007) Resveratrol stimulates glucose transport in C2C12 myotubes by activating AMP-activated protein kinase. Exp Mol Med;39:222229.
  • 19
    Zang M., Xu S., Maitland-Toolan K.A., Zuccollo A., Hou X., Jiang B., Wierzbicki M., Verbeuren T.J., Cohen R.A. (2006) Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes;55:21802191.
  • 20
    Feige J.N., Lagouge M., Canto C., Strehle A., Houten S.M., Milne J.C., Lambert P.D., Mataki C., Elliott P.J., Auwerx J. (2008) Specific SIRT1 activation mimics low energy levels and protects against diet-induced metabolic disorders by enhancing fat oxidation. Cell Metab;8:347358.