• 1
    Guerin P.J., Olliaro P., Sundar S., Boelaert M., Croft S.L., Desjeux P., Wasunna M.K., Bryceson A.D. (2002) Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect Dis;2:494501.
  • 2
    Piñero J., Temporal R.M., Silva-Goncalves A.J., Jiménez I.A., Bazzocchi I.L., Oliva A., Perera A., Leonb L.L., Valladares B. (2006) New administration model of trans-chalcone biodegradable polymers for the treatment of experimental leishmaniasis. Acta Trop;98:5965.
  • 3
    Croft S.L., Coombs G.H. (2003) Leishmaniasis-current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol;19:502508.
  • 4
    Hemmateenejad B., Miri R., Niroomand U., Foroumadi A., Shafiee A. (2007) A mechanistic QSAR study on the leishmanicidal activity of some 5-substituted-1,3,4-thiadiazole derivatives. Chem Biol Drug Des;69:435443.
  • 5
    Singh S., Sivakumar R.J. (2004) Challenges and new discoveries in the treatment of leishmaniasis. J Infect Chemother;10:307315.
  • 6
    Di Carlo G., Mascolo N., Izzo A.A., Capasso F. (1999) Flavonoids: old and new aspects of a class of natural therapeutic drugs. Life Sci;65:337353.
  • 7
    Go M.L., Wu X., Liu X.L. (2005) Chalcones: an update on cytotoxic and chemoprotective properties. Curr Med Chem;12:481499.
  • 8
    Hsieh H.K., Lee T.H., Wang J.P., Wang J.J., Lin C.N. (1998) Synthesis and anti-inflammatory effect of chalcones and related compounds. Pharm Res;15:3946.
  • 9
    Barford L., Kemp K., Hansen M., Kharazmi A. (2002) Chalcones from Chinese liquorice inhibit proliferation of T cells and production of cytokines. Int Immunopharmacol;2:545–555.
  • 10
    Sivakumar P.M., Muthu Kumar T., Doble M. (2009) Antifungal activity, mechanism and QSAR studies on chalcones. Chem Biol Drug Des;74:6879.
  • 11
    Nam N.H., Kim Y., You Y.J., Hong D.H., Kim H.M., Ahn B.Z. (2003) Cytotoxic 2′,5′-dihydroxychalcones with unexpected antiangiogenic activity. Eur J Med Chem;38:179187.
  • 12
    Lawrence N.J., Rannison D., McGown A.T., Ducki S., Gul L.A., Hadfield J.A., Khan N. (2001) Linked parallel synthesis and MTT bioassay screening of substituted chalcones. J Comb Chem;3:421426.
  • 13
    Yaylı N., Üçüncü O., Yaşar A., Gök Y., Küçük M., Kolaylı S. (2004) Stereoselective photochemistry of methoxy chalcones in solution and their radical scavenging activity. Turk J Chem;28:515521.
  • 14
    Sivakumar P.M., Priya S., Doble M. (2009) Synthesis, biological evaluation, mechanism of action and quantitative structure-activity relationship studies of chalcones as antibacterial agents. Chem Biol Drug Des;73:403415.
  • 15
    Xue C.X., Cui S.Y., Liu M.C., Hu Z.D., Fan B.T. (2004) 3D QSAR studies on antimalarial alkoxylated and hydroxylated chalcones by CoMFA and CoMSIA. Eur J Med Chem;39:745753.
  • 16
    Liu M., Wiliarat P., Go M.L. (2001) Antimalarial alkoxylated and hydroxylated chalones: structure-activity relationship analysis. J Med Chem;44:44434452.
  • 17
    Liu M., Wilairat P., Croft S.L., Tan A.L., Go M.L. (2003) Structure–activity relationships of antileishmanial and antimalarial chalcones. Bioorg Med Chem;11:27292738.
  • 18
    Chen M., Christensen S.B., Theander T.G., Kharazmi A. (1994) Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani. Antimicrob Agents Chemother;38:13391344.
  • 19
    Nowakowska Z. (2007) A review of anti-infective and anti-inflammatory chalcones. Eur J Med Chem;42:125137.
  • 20
    Kumar J.K., Narender T., Rao M.S., Rao P.S., Toth G., Balazs B., Duddeck H. (1999) Further Dihydrochalcones from Crotolaria ramosissima. J Braz Chem Soc;10:278280.
  • 21
    Narender T., Shweta, Gupta S. (2004) A convenient and biogenetic type synthesis of few naturally occurring chromeno dihydrochalcones and their in vitro antileishmanial activity. Bioorg Med Chem Lett;14:39133916.
  • 22
    Nazarian Z., Emami S., Heydari S., Ardestani S.K., Nakhjiri M., Poorrajab F., Shafiee A., Foroumadi A. (2010) Novel antileishmanial chalconoids: synthesis and biological activity of 1- or 3-(6-chloro-2H-chromen-3-yl)propen-1-ones. Eur J Med Chem; In press: doi:10.1016/j.ejmech.2009.12.046.
  • 23
    Sorkhi M., Forouzani M., Dehghan G., Abdolahi M., Shafiee A., Foroumadi A. (2008) Synthesis and evaluation of antioxidant activity of 6-methoxy-2H-chromenes. Asian J Chem;20:21512155.
  • 24
    Behrouzi-Fardmoghadam M., Poorrajab F., Ardestani S.K., Emami S., Foroumadi A., Shafiee A. (2008) Synthesis and in vitro anti-leishmanial activity of 1-[5-(5-nitrofuran-2-yl)-1,3,4-thiadiazol-2-yl]- and 1-[5-(5-nitrothiophen-2-yl)-1,3,4-thiadiazol-2-yl]-4-aroylpiperazines. Bioorg Med Chem;16:45094515.
  • 25
    Dutta A., Bandyopadhyay S., Mandal C., Chatterjee M. (2005) Development of a modified MTT assay for screening antimonial resistant field isolates of Indian visceral leishmaniasis. Parasitol Int;54:119122.
  • 26
    Nielsen A.T., Houlihan W.J. (1968) The aldol condensation. Org React;16:1438.
  • 27
    Fine S.A., Pulaski P.D. (1973) Reexamination of the Claisen-Schmidt condensation of phenylacetone with aromatic aldehydes. J Org Chem;38:17471749.
  • 28
    Nielsen S.F., Christensen S.B., Cruciani G., Kharazmi A., Liljefors T. (1998) Antileishmanial chalcones: statistical design, synthesis, and three- dimensional quantitative structure-activity relationship analysis. J Med Chem;41:48194832.
  • 29
    Kayser O., Kiderlen A.F. (2001) In vitro leishmanicidal activity of naturally occurring chalcones. Phytother Res;15:148152.
  • 30
    Chen M., Zhai L., Brogger S., Christensen S.B., Theander T.G., Kharazmi A. (2001) Inhibition of fumarate reductase in Leishmania major and L. donovani by chalcones. Antimicrob Agents Chemother;45:20232029.
  • 31
    Zhai L., Blom J., Chen M., Christensen S.B., Kharazmi A. (1995) The antileishmanial agent licochalcone A interferes with the function of parasite mitochondria. Antimicrob Agents Chemother;39:27422748.
  • 32
    Zhai L., Chen M., Blom J., Christensen S.B., Theander T.G., Kharazmi A. (1999) The antileishmanial activity of novel oxygenated chalcones and their mechanism of action. J Antimicrob Chemother;43:793803.