• 1
    Kahn B.B., Alquier T., Carling D., Hardie D.G. (2005) AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab;1:1525.
  • 2
    Xiao B., Heath R., Saiu P., Leiper F.C., Leone P., Jing C., Walker P.A., Haire L., Eccleston J.F., Davis C.T. (2007) Structural basis for AMP binding to mammalian AMP-activated protein kinase. Nature;449:496500.
  • 3
    Hardie D.G., Hawley S.A. (2001) AMP-activated protein kinase: the energy charge hypothesis revisited. Bioessays;23:11121119.
  • 4
    Cool B., Zinker B., Chiou W., Kifle L., Cao N., Perham M., Dickinson R. et al. (2006) Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cell Metab;3:403416.
  • 5
    Yamanaka G., Wilson T., Innaimo S., Bisacchi G.S., Egli P., Rinehart J.K., Zahler R., Colonno R.J. (1999) Metabolic studies on BMS-200475, a new antiviral compound active against hepatitis B virus. Antimicrob Agents Chemother;43:190193.
  • 6
    Gruber H.E. US Patent 5,658,889, August 19, 1997.
  • 7
    Mueller W.E.G., Weiler B.E., Charubala R., Pfleiderer W., Leserman L., Sobol R.W., Suhadolnik R.J., Schroeder H.C. (1991) Cordycepin analogues of oligoadenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase. Biochem Wash;30:20272033.
  • 8
    Sugar A.M., McCaffrey R.P. (1998) Antifungal activity of 3′-deoxyadenosine (cordycepin). Antimicrob Agents Chemother;42:14241427.
  • 9
    Okoshi R., Ozaki T., Yamamoto H., Ando K., Koida N., Ono S., Koda T., Kamijo T., Nakagawara A., Kizaki H. (2008) Activation of AMP-activated protein kinase induces p53-dependent apoptotic cell death in response to energetic stress. J Biol Chem;283:39793987.
  • 10
    Wong Y.Y., Moon A., Duffin R., Barthet-Barateig A., Meijer H.A., Clemens M.J., De Moor C.H. (2010) Cordycepin inhibits protein synthesis and cell adhesion through effects on signal transduction. J Biol Chem;285:26102621.
  • 11
    Morris G.M., Goodshell D.S., Halliday R.S., Huey R., Hart W.E., Belew R.K., Olson A.J. (1998) Automated docking using a Lamarckian genetic algorithm and empirical binding free energy function. J Comput Chem;19:16391662.
  • 12
    Townley R., Shapiro L. (2007) Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science;315:17261729.
  • 13
    Zsoldos Z., Reid D., Simon A., Sadjad B.S., Johnson A.P. (2006) eHiTS: an innovative approach to the docking and scoring function problems. Curr Protein Pept Sci;7:421435.
  • 14
    Ko H.J., Zhang Z., Jung D.Y., Jun J.Y., Ma Z., Jones K.E., Chan S.Y., Kim J.K. (2009) Nutrient stress activates inflammation and reduces glucose metabolism by suppressing AMP-activated protein kinase in the heart. Diabetes;58:25362546.
  • 15
    Gruzman A., Babai G., Sasson S. (2009) Adenosine monophosphate-activated protein kinase (AMPK) as a new target for antidiabetic drugs: a review on metabolic, pharmacological and chemical considerations. Rev Diabet Stud;6:1336.
  • 16
    Guo D., Hildebrandt I.J., Prins R.M., Soto H., Mazzotta M.M., Dang J., Czernin J., Shyy J.Y., Watson A.D., Phelps M., Radu C.G., Cloughesy T.F., Mischel P.S. (2009) The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A;106:1293212937.
  • 17
    Erion M.D., Dang Q., Reddy M.R., Kasibhatla S.R., Huang J., Lipscomb W.N., Van Poelje P.D. (2007) Structure-guided design of AMP mimics that inhibit fructose-1, 6- bisphosphatase with high affinity and specificity. J Am Chem Soc;129:1548015490.
  • 18
    Reddy M.R., Erion M.D. (2001) Calculation of relative binding free energy differences for fructose 1, 6-bisphosphatase inhibitors using the thermodynamic cycle perturbation approach. J Am Chem Soc;123:62466252.
  • 19
    Reddy M.R., Erion M.D. (2007) Relative binding affinities of fructose-1,6- bisphosphatase inhibitors calculated using a quantum mechanics-based free energy perturbation method. J Am Chem Soc;129:92969297.