CoMSIA Study on Substituted Aryl Alkanoic Acid Analogs as GPR40 Agonists
Version of Record online: 25 MAR 2011
© 2011 John Wiley & Sons A/S
Chemical Biology & Drug Design
Volume 77, Issue 5, pages 361–372, May 2011
How to Cite
Bhatt, A., Patel, P. D., Patel, M. R., Singh, S., Lau-Cam, C. A. and Talele, T. T. (2011), CoMSIA Study on Substituted Aryl Alkanoic Acid Analogs as GPR40 Agonists. Chemical Biology & Drug Design, 77: 361–372. doi: 10.1111/j.1747-0285.2011.01112.x
- Issue online: 13 APR 2011
- Version of Record online: 25 MAR 2011
- Accepted manuscript online: 26 FEB 2011 10:10AM EST
- Received 29 November 2010, revised 12 January 2011 and accepted for publication 20 February 2011
Figure S1. Receptor Based Model where the dataset was aligned onto the template molecule 16 using the manual atom fit alignment.
Table S1. Summary of CoMFA statistical results for the GPR40 activity.
Table S2. Comparision of CoMSIA results for the ligand- and the receptor-based models.
Table S3. Observed and predicted pEC50 values of the diverse set of GPR40 agonists.
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