Both authors contributed equally to this paper.
Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan
Article first published online: 28 NOV 2011
© 2011 John Wiley & Sons A/S
Chemical Biology & Drug Design
Volume 79, Issue 1, pages 121–127, January 2012
How to Cite
Cui, Z.-N., Shi, Y.-X., Cui, J.-R., Ling, Y., Li, B.-J. and Yang, X.-L. (2012), Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan. Chemical Biology & Drug Design, 79: 121–127. doi: 10.1111/j.1747-0285.2011.01266.x
- Issue published online: 19 DEC 2011
- Article first published online: 28 NOV 2011
- Accepted manuscript online: 24 OCT 2011 11:45AM EST
- Received 12 March 2011, revised 30 September 2011 and accepted 4 October 2011
- antifungal activity;
- antitumor activity;
- pyrazole and triazole derivatives;
A series of novel pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized. Their toxicities were predicted using in silico assays and proven to be less toxic. The antitumor results showed that the activity of compounds containing 1,3,4-triazole (series II) was higher than that of pyrazole-attached derivatives (series I). Among them, IIa and IIg showed much higher activity against Bel-7402 than doxorubicin. The fungicidal tests showed that most title compounds II exhibited great selectivity against Phytophthora capsici in vivo.