Synthesis and Bioactivities of Novel Pyrazole and Triazole Derivatives Containing 5-Phenyl-2-Furan

Authors

  • Zi-Ning Cui,

    1. Department of Applied Chemistry, College of Science, China Agricultural University, Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Beijing 100193, China
    Search for more papers by this author
    • Both authors contributed equally to this paper.

  • Yan-Xia Shi,

    1. Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    Search for more papers by this author
    • Both authors contributed equally to this paper.

  • Jing-Rong Cui,

    1. State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China
    Search for more papers by this author
  • Yun Ling,

    1. Department of Applied Chemistry, College of Science, China Agricultural University, Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Beijing 100193, China
    Search for more papers by this author
  • Bao-Ju Li,

    1. Institute of Vegetables and Flowers, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    Search for more papers by this author
  • Xin-Ling Yang

    Corresponding author
    1. Department of Applied Chemistry, College of Science, China Agricultural University, Key Laboratory of Pesticide Chemistry and Application, Ministry of Agriculture, Beijing 100193, China
      *Corresponding author: Xin-Ling Yang, yangxl@cau.edu.cn.
    Search for more papers by this author

*Corresponding author: Xin-Ling Yang, yangxl@cau.edu.cn.

Abstract

A series of novel pyrazole and triazole derivatives containing 5-phenyl-2-furan functionality were designed and synthesized. Their toxicities were predicted using in silico assays and proven to be less toxic. The antitumor results showed that the activity of compounds containing 1,3,4-triazole (series II) was higher than that of pyrazole-attached derivatives (series I). Among them, IIa and IIg showed much higher activity against Bel-7402 than doxorubicin. The fungicidal tests showed that most title compounds II exhibited great selectivity against Phytophthora capsici in vivo.

Ancillary