• 1
    Tedesco R., Shaw A.N., Bambal R., Chai D., Concha N.O., Darcy M.G., Dhanak D. et al. (2006) 3-(1,1-Dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase. J Med Chem;49:971983.
  • 2
    Yoneda T., Sasaki A., Dustan C., William P.J., Bauss F., De Clerck Y.A., Mundy G.R. (1997) Inhibition of osteolytic bone metastasis of breast cancer by combined treatment with the bisphosphonate ibandronate and tissue inhibitor of the matrix metalloproteinase-2. J Clin Invest;99:25092517.
  • 3
    Lipton A., Theriault R.L., Hortobagyi G.N., Simeone J., Knight R.D., Mellars K., Reitsma D.J., Heffernan M., Seaman J. (2000) Pamidronate prevents skeletal complications and is effective palliative treatment in women with breast carcinoma and osteolytic bone metastases. J Cancer;88:10821090.
  • 4
    Busch M., Rave-Frank M., Hille A., Duhmke E. (1998) Influence of clodronate on breast cancer cells in vitro. Eur J Med Res;3:427431.
  • 5
    Diel I.J., Marschner N., Kindler M., Lange O., Untch M., Hurtz H.J., Bre-itbach G.P., Richter B. (1999) Continual oral versus intravenous interval therapy with bisphosphonates in patients with breast cancer and bone metastases. Proc ASCO;18:128.
  • 6
    Small E.J., Smith M.R., Seaman J.J., Petrone S., Kowalski M.O. (2003) Combined analysis of two multicenter, randomized, placebo-controlled studies of pamidronate disodium for the palliation of bone pain in men with metastatic prostate cancer. J Clin Oncol;21:42614262.
  • 7
    Abdou W.M., Kamel A.A., Shaddy A.A. (2010) Use of phosphonyl carbanions in the synthesis of anti-inflammatory active phosphorus-containing fused heterocycles and relevance phosphonates. Eur J Med Chem;45:52175224.
  • 8
    Abdou W.M., Khidre R.E., Shaddy A.A. (2012) Chemical synthesis of anti-inflammatory tetrazoloquinoline–based mono and bisphosphonate esters. J Heterocyclic Chem;in press.
  • 9
    Shaddy A.A., Kamel W.M., Abdou A.A. (2012) Synthesis, quantitative structure-activity relationship (QSAR), and anti-inflammatory profiles of substituted 5- and 6-N-heterocycle bisphosphonate esters. Synth Commun;in press.
  • 10
    Abdou W.M., Shaddy A.A. (2010) An efficient practical synthesis of thiobis-phosphonic acids for the treatment of arthritis, based on the chemistry of disulfides. J Med Chem Res;19:3940.
  • 11
    Abdou W.M., Shaddy A.A. (2009) The development of bisphosphonates for therapeutic uses and bisphosphonate structure-activity consideration. Arkivoc;14:143182.
  • 12
    Abdou W.M., Ganoub N.A., Geronikaki A., Sabry E. (2008) Synthesis, properties, and perspectives of gem-diphosphono substituted-thiazoles. Eur J Med Chem;43:10151024.
  • 13
    Abdou W.M., Khidre M.D., Sediek A.A. (2006) A practical synthesis of thio-bisphosphonic acids for the treatment of arthritis, based on the chemistry of tetraethyl methylene-1,1-bisphosphonate. Lett Org Chem;3:634640.
  • 14
    Abdou W.M., Ganoub N.A., Fahmy A.F.M., Shaddy A.A. (2006) Symmetrical and asymmetrical bisphosphonate esters. Synthesis, selective hydrolysis, and isomerization. Monatsh Chem;136:105116.
  • 15
    Abdou W.M., Khidre R.E., Kamel A.A. (2012) Elaborating on efficient anti-proliferation agents of cancer cells and antiinflammatory-based N-bisphosphonic acids. Arch Pharm Chem Life Sci;345:123136.
  • 16
    Stepanchikova A.V., Lagunin A.A., Filimonov D.A., Poroikov V.V. (2003) Prediction of biological activity spectra for substances: evaluation on the diverse set of drug-like structures. Curr Med Chem;10:225233.
  • 17
    Poroikov V.V., Filimonov D.A., Borodina Yu.V., Lagunin A.A., Kos A. (2000) Robustness of biological activity spectra predicting by computer program pass for non-congeneric sets of chemical compounds. J Chem Inf Comput Sci;40:13491355.
  • 18
    Poroikov V.V., Filimonov D.A. (2003) How to acquire new biological activities in old compounds by computer prediction. J Comput Aid Mol Des;16:819824. Available at: (accessed at May 2011).
  • 19
    Da Silva C.H., Da Silva V.B., Resende J., Rodrigues P.F., Bononi F.C., Benevenuto C.G., Taft C.A. (2010) Computer-aided drug design and ADMET predictions for identification and evaluation of novel potential farnesyltransferase inhibitors in cancer therapy. J Mol Graph Modeling;28:513523.
  • 20
    Mustafayeva K., Di Giorgio C., Elias R., Kerimov Y., Evelyne O.E., Michel D.M. (2010) DNA-Damaging, mutagenic, and clastogenic activities of gentiopicroside isolated from Cephalaria kotschyi roots. J Nat Prod;73:99103.
  • 21
    Benchabane Y., Di Giorgio C., Boyer G., Sabatier A.S., Allegro D., Peyrot V., De Méo M. (2009) Photo-inducible cytotoxic and clastogenic activities of 3,6-disubstituted acridines obtained by acylation of proflavine. Eur J Med Chem;44:24592467.
  • 22
    Geronikaki A.A., Dearden J.C., Filimonov D., Galava I., Garibova T.L., Gloriozova T., Kraineva V. et al. (2004) Design of new cognition enhancers: from computer prediction to synthesis and biological evaluation. J Med Chem;47:28702876.
  • 23
    Chapman E., Stephen H. (1925) The preparation of phthalamic acids and their conversion into anthranilic acids. J Chem Soc Trans;127:17911797.
  • 24
    Baddar F.G., Fahmy A.F.M., Aly N.F. (1973) 2,3-Benzoxazin-1-ones. Part I. Reactions of aluminum chloride, sulphuric acid, and hydrazine hydrate with 4-aryl-2,3-benzoxazin-1-ones. J Chem Soc Perkin Trans I;24482450.
  • 25
    Nanda A.K., Ganguli S., Chakraborty R. (2007) Antibacterial activity of some 3-(arylideneamino)-2-phenylquinazoline-4(3H)-ones: synthesis and preliminary QSAR studies. Molecules;12:24132426.
  • 26
    Abdou W.M., Fahmy A.F.M., Kamel A.A. (2002) Study of insertion reactions with phosphorus ylides. On reactions between 4-(4-methylphenyl)-2,3-benzoxazin-1-one and alkylidene phosphoranes. Eur J Org Chem;10:16961701.
  • 27
    Abdou W.M., Kamel A.A., Khidre M.D. (2004) Phosphono substituted-isoindolines and indoles from 2,3- and 2,4-benzoxazin-1-ones. Heteroatom Chem;15:7784.
  • 28
    Abdou W.M., Kamel A.A., Khidre M.D. (2004) Further insight into the reactivity of oxazinones toward phosphorus reagents. Synth Commun;34:41194134.
  • 29
    Abdou W.M., Kamel A.A. (2007) Remarkably efficient and direct route to quinolines and benzoazepines from the condensation of benzoxazinediones with phosphonium carbanion salts. Synth Commun;37:39453960.
  • 30
    Kamel A.A., Abdou W.M. (2007) Alkylidenephosphoranes in heterocyclic synthesis. Reactivity of benzoxazinones with resonance-stabilized phosphorus ylides. Synlett;12691273.
  • 31
    Hardtmann G.E., Huegi B.S., Gogerty J.H., Iorio L.C., Barnes H.W. (1971) Tetracyclic quinazolinone derivatives. J Med Chem;14:878882.
  • 32
    Zentmyer D.T., Wagner E.C. (1949) The so-called acylanthranils (3,1,4-benzooxazines). I. Preparation; reactions with water, ammonia, and aniline; structure. J Org Chem;14:967981.
  • 33
    Koz’minykh E.N., Goncharov V.I., Aitken R.A., Koz’minykh V.O., Lomidze K.Sh. (2006) An unusual reaction of isatoic anhydride with acetyl- and benzoylmethylene-triphenylphosphoranes. Chem Heterocyclic Compds;42:11071108.
  • 34
    Turhanen P.A., Vepsäläinen J.J. (2008) Unexpected degradation of the Bisphosphonate P-C-P bridge under mild conditions. Beilstein J Org Chem;4(7):15.
  • 35
    Gibson S.E., Haycock P.R., Miyazaki A. (2009) Cyclisation of bisphosphonate substituted enynes. Tetrahedron;65:74987503.
  • 36
    Du Y., Jung K.Y., Wiemer D.F. (2002) A one-flask synthesis of α,α-bisphosphonates via enolate chemistry. Tetrahedron Lett;43:86658668.
  • 37
    Migianu E., Mallard I., Bouchemal N., Lecouvey M. (2004) One-pot synthesis of 1-hydroxymethylene-1,1-bisphosphonate partial esters. Tetrahedron Lett;45:45114513.
  • 38
    Neidlein R., Eichinger T. (1992) Substituted methylphosphonates as synthons for alicyclic α-function- alized phosphonates. Monatsh Chem;123:10371043.
  • 39
    Kruikuv V.I., Erkin A.V., Zolotukhina M.M. (2003) Heteryl- and Arylamino-methylene-bisphosphonates: synthesis and biologic activity. Russ J Gen Chem;23:187191.
  • 40
    Szłyk E., Wojtczak A., Dobrzańska L., Barwiołek V. (2008) X-ray crystal structure and nuclear Overhauser effect studies of cerium(IV) complexes with Schiff bases obtained from N,N′-(1R,2R)(−)-1,2-cyclohexanediamine and benzaldehyde derivatives. Polyhedron;27:765776.
  • 41
    Mourelatos D. (1996) Chromosome study as predictor of chemo response of tumours. Cancer J;9:136141.
  • 42
    Mourelatos D., Mylonaki E., Papageorgiou A., Boutis L., Paradelis A., Anastasiou A., Catsoulacos P. (1995) Comparative study of SCE induction and cytostatic effects by homo-azasteroidal esters of N,N-bis(2-chloroethyl)aminobenzoic acid in human lymphocytes. Mutat Res;346:129133.
  • 43
    Van den Wyngaert T., Huizing M.T., Fossion E., Vermorken J.B. (2009) Bisphosphonates in oncology: rising stars or fallen heroes. Oncologist;14:181191.
  • 44
    Goto K., Maeda S., Kano Y., Sugiyaama T. (1978) Factors involved in differential giemsa staining of sister chromatids. Chromosoma;66:351359.