• 1
    Grimaldi R., Tesh G.R., McMahon-Pratt C. (1989) A review of the geographic distribution and epidemiology of leishmaniasis in the New World. Am J Trop Med Hyg;41:687725.
  • 2
    Herwalt B.L. (1999) Leishmaniasis Lancet;354:11911199.
  • 3
    Mrozek A., Karolak-Wojciechowska J., Bsiri N., Barbe J. (2000) Quantitative analysis of structure-activity relationship in the acridine serie. Part 1. Antiparasitic 9-thioaryl-acridine derivatives. Acta Pol Pharm;57:345351.
  • 4
    DasGupta B.M., Dikshit B.B. (1929) Berberine in treatment of oriental sore. Indian Med Gaz;64:6770.
  • 5
    Leon W., Brun R., Krassner S.M. (1977) Effect of berenil on growth, mitochondrial DNA and respiration of Leishmania tarentolae promastigotes. J Eukaryot Microbiol;24:444448.
  • 6
    Ghosh A.K., Rakshit M.M., Ghosh D.K. (1983) Effect of berberine chloride on Leishmania donovani. Indian J Med Res;78:407416.
  • 7
    Ghosh A.K., Bhattacharyya F.K., Ghosh D.K. (1985) Leishmania donovani: amastigote inhibition and mode of action of berberine. Exp Parasitol;60:404413.
  • 8
    Shapiro T.A., Englund P.T. (1990) Selective cleavage of kinetoplast DNA minicircles promoted by antitrypanosomal drugs. Proc Natl Acad Sci U S A;87:950954.
  • 9
    Vennerstrom J.L., Lovelace J.K., Waits V.B., Hanson W.L., Klayman D.L. (1990) Berberine derivatives as antileishmanial drugs. Antimicrob Agents Chemother;34:918921.
  • 10
    Edwards K.J., Jenkins T.C., Neidle S. (1992) Crystal structure of a pentamidine-oligonucleotide complex: implications for DNA-binding properties. Biochemistry;31:71047109.
  • 11
    Stephens C.E., Brun R., Salem M.M., Werbovetz K.A., Tanious F., Wilson W.D., Boykin D.W. (2003) The activity of diguanidino and ‘reversed’ diamidino 2,5-diarylfurans versus Trypanosoma cruzi and Leishmania donovani. Bioorg Med Chem Lett;13:20652069.
  • 12
    Giorgio C.D., Shimi K., Boyer G., Delmas F., Galy J.P. (2007) Synthesis and antileishmanial activity of 6-mono-substituted and 3,6-di-substituted acridines obtained by acylation of proflavine. Eur J Med Chem;42:12771284.
  • 13
    Hu L., Arafa R.K., Ismail M.A., Wenzler T., Brun R., Munde M., Wilson W.D., Nzimiro S., Samyesudhas S., Werbovetz K.A., Boykin D.W. (2008) Azaterphenyl diamidines as antileishmanial agents. Bioorg Med Chem Lett;18:247251.
  • 14
    Chavda S., Babu B., Yanow S.K., Jardim A., Spithill T.W., Kiakos K., Kluza J., Hartley J.A., Lee M. (2010) A novel achiral seco-cyclopropylpyrido[e]indolone (CPyI) analog of CC-1065 and the duocarmycins: synthesis, DNA interactions, in vivo anticancer and anti-parasitic evaluation. Bioorg Med Chem;18:50165024.
  • 15
    Coletta A., Rocca B.M.D., Jaisankar P., Majumder H.K., Chillemi J., Sanna N., Desideri A. (2010) Assignment of UV-vis spectrum of (3,3′)-diindolylmethane, a Leishmania donowani topoisomerase IB inhibitor and a candidate DNA minor groove binder. J Phys Chem A;114:71217126.
  • 16
    Friesner R.A., Banks J.L., Murphy R.B., Halgren T.A., Klicic J.J., Mainz D.T., Repasky M.P., Knoll E.H., Shelley M., Perry J.K., Shaw D.E., Francis P., Shenkin P.S. (2004) Glide, A New approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy. J Med Chem;47:17391749.
  • 17
    Lipinski C.A, Lombardo F., Dominy B.W., Feeney P.J. (1997) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Delivery Rev;23:325.
  • 18
    Lipinski C.A. (2000) Drug-like properties and the causes of poor solubility and poor permeability. J Pharm Tox Meth;44:235249.
  • 19
    Gamage S.A., Figgit D.P., Wojcik S.J., Ralph R.K., Ransijn A., Mauel J., Yardley V., Snowdon D.S., Croft L., Denny W. (1997) Structure-activity relationships for the antileishmanial and antitrypanosomal activities of 1′-substituted 9-anilino-acridines. J Med Chem;40:26342642.
  • 20
    Girault S., Delarue S., Grellier P., Berecibar A., Maes L., Quirijnen L., Lemiere P., Debreu-Fontaine M.A., Sergheraert C. (2001) Antimalarial in-vivo activity of bis(9-amino-6-chloro-2-methoxyacridines). J Pharm Pharmacol;53:935938.
  • 21
    Anderson M.O., Sherrill J., Madrid P.B., Liou A.P., Weisman J.L., DeRisi J.L., Guy R.K. (2006) Parallel synthesis of 9-aminoacridines and their evaluation against chloroquine-resistant Plasmodium falciparum. Bioorg Med Chem;14:334343.
  • 22
    Putzer B. (1934) Berberine and its derivatives in the treatment of oriental sore. Med Chem Aspects;2:274280.
  • 23
    Ferraroni M., Bazzicalupi C., Bilia A.R., Gratteri P. (2011) X-Ray diffraction analyses of the natural isoquinoline alkaloids Berberine and Sanguinarine complexed with double helix DNA d(CGTACG). Chem Commun;47:49174919.
  • 24
    Lane A.N., Jenkins T.C., Brown T., Stephen N. (1991) Interaction of berenil with the EcoRI dodecamer d(CGCGAATTCGCG)2 in solution studied by NMR. Biochemistry;30:13721385.
  • 25
    Vercesi A.E., Docampo R. (1992) Ca2 + transport by digitonin-permeabilized Leishmania donovani. Effect of Ca2 + , pentamidine and WR-6026 on mitochondrial membrane potential in situ. Biochem J;284:463467.
  • 26
    Cain B.F., Atwell G.J., Seelye R.N. (1969) Potential antitumour agents. X. Bisquaternary salts. J Med Chem;12:199206.
  • 27
    Goodsell D., Dickerson R.E. (1986) Isohelical analysis of DNA groove-binding drugs. J Med Chem;29:727733.
  • 28
    Brendle J.J., Outlaw A., Kumar A., Boykin D.W., Patrick D.A., Tidwell R.R., Werbovetz K.A. (2002) Antileishmanial activities of several classes of aromatic dications. Antimicrob Agents Chemother;46:797807.
  • 29
    Boger D. L., Johnson D.S. (1995) CC-1065 and the duocarmycins: unraveling the keys to a new class of naturally derived DNA alkylating agents. Proc Natl Acad Sci U S A;92:36423649.