• 1
    Lee S.W., Chung S.S. (2010) A review of the effects of vitamins and other dietary supplements on seizure activity. Epilepsy Behav;18:139150.
  • 2
    Sander J.W. (2003) The epidemiology of epilepsy revisited. Curr Opin Neurol;16:165170.
  • 3
    Tsang S.Y., Xue H. (2004) Development of effective therapeutics targeting the GABAA receptor: naturally occurring alternatives. Curr Pharm Des;10:10351044.
  • 4
    Medina J.H., Paladini A.C., Wolfman C., Levi de Stein M., Calvo D., Diaz L.E., Peña C. (1990) Chrysin (5-7- di- OH- flavone), a naturally-occurring ligand for benzodiazepine receptors with anticonvulsant properties. Biochem Pharmacol;40:22272231.
  • 5
    Gupta R., Singh M., Sharma A. (2003) Neuroprotective effect of antioxidants on ischaemia and reperfusion-induced cerebral injury. Pharmacol Res;48:209215.
  • 6
    Marder M., Paladini A.C. (2002) GABAA-receptor ligands of flavonoid structure. Curr Top Med Chem;2:853867.
  • 7
    Medina J.H., Viola H., Wolfman C., Marder M., Wasowski C., Calvo D., Paladini A.C. (1997) Overview- flavonoids: a new family of benzodiazepine receptor ligands. Neurochem Res;22:419425.
  • 8
    Kahnberg P., Lager E., Rosenberg C., Schougaard J., Camet L., Sterner O., Østergaard Nielsen E., Liliefors T. (2002) Refinement and evaluation of a pharmacophore model for flavone derivatives binding to the benzodiazepine site of the GABA (A) receptor. J Med Chem;45:41884201.
  • 9
    Fernandez S.P., Wasowski C., Loscalzo L.M., Granger R.E., Johnston G.A., Paladini A.C., Marder M. (2006) Central nervous system depressant action of flavonoid glycosides. Eur J Pharmacol;539:168176.
  • 10
    Wasowski C., Marder M., Viola H., Medina J.H., Paladini A.C. (2002) Isolation and identification of 6-methylapigenin, a competitive ligand for the brain GABAA receptors, from Valeriana wallichii D.C. Planta Med;68:934936.
  • 11
    Paladini A.C., Marder M., Viola H., Wolfman C., Wasowski C., Medina J.H. (1999) Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds. J Pharm Pharmacol;51:519526.
  • 12
    Li Y.L., Ma S.C., Yang Y.T., Ye S.M., But P.P. (2002) Antiviral activities of flavonoids and organic acid from Trollius chinensis Bunge. J Ethnopharmacol;79:365368.
  • 13
    Ragone M.I., Sella M., Conforti P., Volonte M., Consolini A.E. (2007) The spasmolytic effect of Aloysia citriodora, Palau (South American cedron) is partially due to its vitexin but not isovitexin on rat duodenums. J Ethnopharmacol;113:258266.
  • 14
    Gorzalczany S., Marrassini C., Mino J., Acevedo C., Ferraro G. (2011) Antinociceptive activity of ethanolic extract and isolated compounds of Urtica circularis. J Ethnopharmacol;134:733738.
  • 15
    Gilani A.H., Khan A., Ghayur M.N., Ali S.F., Herzig J.W. (2006) Antispasmodic effects of Rooibos Tea (Aspalathus linearis) is mediated predominantly through K+-channel activation. Basic Clin Pharmacol Toxicol;99:365373.
  • 16
    Quílez A., Berenguer B., Gilardoni G., Souccar C., de Mendonc S., Oliveira L.F.S., Martín-Calero M.J. (2010) Anti-secretory, anti-inflammatory and anti-Helicobacter pylori activities of several fractions isolated from Piper carpunya Ruiz & Pav. J Ethnopharmacol;128:583589.
  • 17
    Shibano M., Kakutani K., Taniguchi M., Yasuda M., Baba K. (2008) Antioxidant constituents in the dayflower (Commelina communis L.) and their a-glucosidase-inhibitory activity. J Nat Med;62:349353.
  • 18
    Cao D., Li H., Yi J., Zhang J., Che H., Cao J., Yang Y., Zhu C., Jiang W. (2011) Antioxidant properties of the mung bean flavonoids on alleviating heat stress. PLoS ONE;66:e21071.
  • 19
    Dong L., Fan Y., Shao X., Chen Z. (2011) Vitexin protects against myocardial ischemia/reperfusion injury in Langendorff perfused rat hearts by attenuating inflammatory response and apoptosis. Food Chem Toxicol;49:32113216.
  • 20
    Kim J.H., Lee B.C., Kim J.H., Sim G.S., Lee D.H., Lee K.E., Yun Y.P., Pyo H.B. (2005) The isolation and antioxidative effects of vitexin from Acer palmatum. Arch Pharm Res;28:195202.
  • 21
    Sejima H., Ito M., Kishi K., Tsuda H., Shiraishi H. (1997) Regional excitatory and inhibitory amino acid concentration in pentylenetetrazole kindling and kindled rat brain. Brain Dev;19:171175.
  • 22
    Hansen S.L., Sperling B.B., Sanchez C. (2004) Anticonvulsant and antiepileptogenic effects of GABAA receptor ligands in pentylenetetrazole-kindled mice. Prog Neuropsychopharmacol Biol Psychiatry;28:105113.
  • 23
    Nassiri-Asl M., Shariati-Rad S., Zamansoltani F. (2007) Anticonvulsant effects of aerial parts of Passiflora incarnata extract in mice: involvement of benzodiazepine and opioid receptors. BMC Complement Altern Med;7:26.
  • 24
    Nassiri-Asl M., Zamansoltani F., Shariati-Rad S. (2008) The possible role of GABAA-benzodiazepine receptor for anticonvulsant effects of Pasipay in rats. Chinese J Altern Med;6:11701173.
  • 25
    Nassiri-Asl M., Shariati-Rad S., Zamansoltani F. (2008) Anticonvulsive effects of intracerebroventricular administration of rutin in rats. Prog Neuro-Psychopharmacol Biol Psychiatry;32:989993.
  • 26
    Paxinos G., Watson C. (1998) The Rat Brain in Stereotaxic Coordinates. New York: Academic Press, Inc.
  • 27
    Loscher W., Honack D., Fassbender C.P., Nolting B. (1991) The role of technical, biological and pharmacological factors in the laboratory evaluation of anticonvulsant drugs. III. Pentylenetetrazole seizure models. Epilepsy Res;8:171189.
  • 28
    Viola H., Wolfman C., Marder M., Goutman J.D., Bianchin M., Wasowski C., Calvo D.J., Izquierdo I., Paladini A.C., Medina J.H. (2000) 6-Chloro-3′nitroflavone is a potent ligand for the benzodiazepine binding site of the GABAA receptor devoid of intrinsic activity. Pharmacol Biochem Behav;65:313320.
  • 29
    Hosseinzadeh H., Sadeghnia H.R. (2007) Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine;14:256262.
  • 30
    Lolli L.F., Sato C.M., Romanini C.V., Villas-Boas L.B., Santos C.A.M., de Oliveira R.M. (2007) Possible involvement of GABAA-benzodiazepine receptor in the anxiolytic-like effect induced by Passiflora actinia extracts in mice. J Ethnopharmacol;111:308314.
  • 31
    Grundmann O., Wang J., McGregor G.P., Butterweck V. (2008) Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system. Planta Med;74:17691773.
  • 32
    Elsas S.M., Rossi D.J., Raber J., White G., Seeley C.A., Gregory W.L., Mohr C. (2010) Passiflora incarnata L. (Passion flower) extracts elicit GABA currents in hippocampal neurons in vitro, and show anxiogenic and anticonvulsant effects in vivo, varying with extraction method. Phytomedicine;17:940949.
  • 33
    Appel K., Rose T., Fiebich B., Kammler T., Hoffmann C., Weiss G. (2011) Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res;25:838843.
  • 34
    Hall B.J., Chebib M., Hanrahan J.R., Johnston G.R. (2005) 6-Methylflavanone, a more efficacious positive allosteric modulator of γ -aminobutyric acid (GABA) action at human recombinant α2β2γ2L than at α1β2γ2L and α1β2 GABAA receptors expressed in Xenopus oocytes. Eur J Pharmacol;512:97104.
  • 35
    Youdim K.A., Qaiser M.Z., Begley D.J., Rice-Evans C.A., Abbott N.J. (2004) Flavonoids permeability across an in situ model of the blood–brain barrier. Free Radic Biol Med;36:592604.
  • 36
    Tahanian E., Sanchez L.A., Shiao T.C., Roy R., Annabi B. (2011) Flavonoids targeting of iκB phosphorylation abrogates carcinogen-induced MMP-9 and COX-2 expression in human brain endothelial cells. Drug Des Devel Ther;5:299309.
  • 37
    Dekermendjian K., Kahnberg P., Witt M.R., Sterner O., Nielsen M., Liljefors T. (1999) Structure- activity relationships and molecular modeling analysis of flavonoids binding to the benzodiazepine site of the rat brain GABA (A) receptor complex. J Med Chem;42:43434350.
  • 38
    Campbell E.L., Chebib M., Johnston G.A.R. (2004) The dietary flavonoids apigenin and (−)-epigallocatechin gallate enhance the positive modulation by diazepam of the activation by GABA of recombinant GABAA receptors. Biochem Pharmacol;68:16311638.
  • 39
    Kavvadias D., Sand P., Youdim K.A., Qaiser M.Z., Rice-Evans C., Baur R., Sigel E., Rausch W.D., Riedere P., Schreier P. (2004) The flavones hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood–brain barrier and exhibits anticonvulsive effects. Br J Pharmacol;142:811820.
  • 40
    Wang F., Shing M., Huen Y., Tsang S.Y., Xue H. (2005) Neuroactive flavonoids interacting with GABAA receptor complex. Curr Drug Targets CNS Neurol Disord;4:575585.
  • 41
    Medina J.H., Viola H., Wolfman C., Marder M., Wasowski C., Calvo D., Paladini A.C. (1998) Neuroactive flavonoids: new ligands for the benzodiazepine receptors. Phytomedicine;5:235243.
  • 42
    Zanoli P., Avallone R., Baraldi M. (2000) Behavioral characterisation of the flavonoids apigenin and chrysin. Fitoterapia;71:117123.
  • 43
    Sucher N.J. (2006) Insights from molecular investigations of traditional Chinese herbal stroke medicines: implications for neuroprotective epilepsy therapy. Epilepsy Behav;8:350362.
  • 44
    Newman D.J., Cragg G.M. (2007) Natural products as sources of new drugs over the last 25 years. J Nat Prod;70:461477.
  • 45
    Koehn F.E., Carter G.T. (2005) The evolving role of natural products in drug discovery. Nat Rev Drug Discov;4:206220.