Bartonella Endocarditis in Complex Congenital Heart Disease
Article first published online: 22 JAN 2007
Congenital Heart Disease
Volume 2, Issue 1, pages 79–84, January/February 2007
How to Cite
Hoffman, R. M., AboulHosn, J., Child, J. S. and Pegues, D. A. (2007), Bartonella Endocarditis in Complex Congenital Heart Disease. Congenital Heart Disease, 2: 79–84. doi: 10.1111/j.1747-0803.2007.00077.x
- Issue published online: 22 JAN 2007
- Article first published online: 22 JAN 2007
- Accepted for publication November 8, 2006.
- Double Outlet Right Ventricular;
Bartonella species are an important cause of culture-negative endocarditis, with recognized risk factors of alcoholism, homelessness, cat exposure, and pre-existing valvular disease. We report a case of Bartonella henselae endocarditis in a 36-year-old woman with complex congenital heart disease who presented with a 7-month history of hemolytic anemia, leukocytoclastic vasculitis, and recurrent fevers. Transesophageal echocardiogram revealed vegetations on the patient’s native aortic valve and in the right ventricular to pulmonary artery conduit and associated bioprosthetic valve. Diagnosis of B. henselae was confirmed with serum antibody and polymerase chain reaction (PCR) testing and tissue stains. The patient was treated successfully with surgical resection and prolonged antimicrobial therapy with ceftriaxone, gentamicin, and doxycycline. A review of the literature suggests prosthetic valves and complex congenital heart disease are risk factors for Bartonella endocarditis, and a high index of suspicion with antibody and PCR testing can expedite diagnosis and improve outcomes.