Survival and Health in Liveborn Infants with Transposition of Great Arteries—A Population-based Study

  1. Ester Garne MD1,*,
  2. Maria A. Loane MSc2,
  3. Vera Nelen MD3,
  4. Marian K. Bakker MSc4,
  5. Blanca Gener MD5,
  6. Lenore Abramsky BSc6,
  7. Marie-Claude Addor MD7,
  8. Annette Queisser-Luft MD8

Article first published online: 6 JUN 2007

DOI: 10.1111/j.1747-0803.2007.00093.x

Issue

Congenital Heart Disease

Congenital Heart Disease

Volume 2, Issue 3, pages 165–169, May/June 2007

Additional Information

How to Cite

Garne, E., Loane, M. A., Nelen, V., Bakker, M. K., Gener, B., Abramsky, L., Addor, M.-C. and Queisser-Luft, A. (2007), Survival and Health in Liveborn Infants with Transposition of Great Arteries—A Population-based Study. Congenital Heart Disease, 2: 165–169. doi: 10.1111/j.1747-0803.2007.00093.x

Author Information

  1. 1

    Paediatric Department, Kolding Hospital, Kolding, Denmark;

  2. 2

    University of Ulster, Belfast, UK;

  3. 3

    Provincial Institute for Hygiene, Antwerp, Belgium;

  4. 4

    University of Groningen, Groningen, The Netherlands;

  5. 5

    Universidad Pompeu Fabra, Barcelona, Spain;

  6. 6

    Northwick Park Hospital, Harrow, UK;

  7. 7

    Division Autonome de Genetique Medicale, Lausanne, Switzerland;

  8. 8

    University Children’s Hospital of Mainz, Mainz, Germany

*Ester Garne, MD, Paediatric Department, Kolding Hospital, DK—6000 Kolding, Denmark. Tel: (+45) 7626-2219; Fax: (+45) 7636-3474; E-mail: egarne@health.sdu.dk

Publication History

  1. Issue published online: 6 JUN 2007
  2. Article first published online: 6 JUN 2007
  3. Accepted in final form: March 20, 2007.

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Keywords:

  • TGA;
  • Prenatal Diagnosis;
  • Survival;
  • Normal Health

Abstract

Objective.  To describe treatment, survival, and morbidity for liveborn infants with isolated transposition of great arteries (TGA).

Design.  Population-based data from 7 European registries of congenital malformations (EUROCAT).

Results.  Ninety-seven infants were diagnosed with isolated TGA and livebirth prevalence was 2.0 per 10 000 livebirths. The majority of infants were treated with prostaglandins (83%) and 57% had a catheter atrial septostomia performed. Arterial switch surgery was performed in 78 infants, other or unknown type of surgery was performed in 3 cases, and for 6 infants there was no information on surgery. At 1 year of age 69 infants were alive (71%) and 24 (25%) were dead (4 unknown). There were 10 deaths before surgery and 58% of all deaths took place during the first week. There was no statistically significant regional difference in mortality. Eight infants diagnosed prenatally all survived to 1 year and only 71% of infants diagnosed after birth survived (P = 0.08). Data on morbidity at 1 year of age was available for 57 infants. Fifty-one infants were reported with normal health and development.

Conclusions.  In this population-based study survival for liveborn infants with TGA is lower than in studies published from tertiary centers. Outcome for survivors at 1 year of age seems favorable.

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