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Hyperthermia exacerbates ischaemic brain injury

Authors

  • C. X. Wang,

    Corresponding author
    1. The Central Illinois Neuroscience Foundation, Bloomington, IL, USA
    2. Department of Biological Science, Illinois State University, Normal, IL, USA
      Chen Xu Wang*, 232A FSA, Illinois State University, Normal, IL 61790-4120, USA. Tel: +1 309 438 4494; Fax: +1 309 438 3722; e-mail: cwang@ilstu.edu
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  • A. Stroink,

    1. The Central Illinois Neuroscience Foundation, Bloomington, IL, USA
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  • J. M. Casto,

    1. Department of Biological Science, Illinois State University, Normal, IL, USA
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  • K. Kattner

    1. The Central Illinois Neuroscience Foundation, Bloomington, IL, USA
    2. Department of Biological Science, Illinois State University, Normal, IL, USA
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  • Conflict of interest: None.

  • Funding: This work is supported by CINF career initiative funding and Katter funding.

Chen Xu Wang*, 232A FSA, Illinois State University, Normal, IL 61790-4120, USA. Tel: +1 309 438 4494; Fax: +1 309 438 3722; e-mail: cwang@ilstu.edu

Abstract

Hyperthermia frequently occurs in stroke patients. Hyperthermia negatively correlates with clinical outcome and adversely effects treatment regiments otherwise successful under normothermic conditions. Preclinical studies also demonstrate that hyperthermia converts salvageable penumbra to ischaemic infarct. The present article reviews the knowledge accumulated from both clinical and preclinical studies about hyperthermia and ischaemic brain injury, examines current treatment strategies and discusses future research directions.

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