Conflict of interest: None declared.
The changing face of neurosyphilis
Article first published online: 10 JAN 2011
© 2011 The Authors. International Journal of Stroke © 2011 World Stroke Organization
International Journal of Stroke
Volume 6, Issue 2, pages 136–143, April 2011
How to Cite
Chahine, L. M., Khoriaty, R. N., Tomford, W. J. and Hussain, M. S. (2011), The changing face of neurosyphilis. International Journal of Stroke, 6: 136–143. doi: 10.1111/j.1747-4949.2010.00568.x
- Issue published online: 4 MAR 2011
- Article first published online: 10 JAN 2011
- human immunodeficiency virus;
- meningovascular syphilis;
The incidence of syphilis has increased over the past decade, particularly among HIV-positive patients, and the presenting clinical features have changed since the beginning of the HIV epidemic. The clinical manifestations of neurosyphilis are protean, and include acute stroke. In patients with HIV, the diagnosis and treatment of neurosyphilis is challenging. We review the clinical presentation, pathophysiology, and treatment of neurosyphilis, with emphasis on neurosyphilis in the HIV population, and neurosyphilis as a cause of acute stroke.