Conflict of interest: None declared.
Cerebral small vessel disease: a review of clinical, radiological, and histopathological phenotypes
Article first published online: 24 NOV 2011
© 2011 The Authors. International Journal of Stroke © 2011 World Stroke Organization
International Journal of Stroke
Volume 7, Issue 1, pages 36–46, January 2012
How to Cite
Moran, C., Phan, T. G. and Srikanth, V. K. (2012), Cerebral small vessel disease: a review of clinical, radiological, and histopathological phenotypes. International Journal of Stroke, 7: 36–46. doi: 10.1111/j.1747-4949.2011.00725.x
- Issue published online: 20 DEC 2011
- Article first published online: 24 NOV 2011
- cerebral small vessel disease;
Cerebral small vessel disease is difficult to directly visualize in vivo. Therefore, we rely on radiological phenotypes as surrogate markers of disease. The principal phenotypes of clinical interest are small, deep brain infarcts, cerebral white matter lesions, deep brain haemorrhages, and cerebral microbleeds. The causes or mechanisms underlying these phenotypes are understood in varying degrees of detail. This review aims to summarize recent knowledge regarding these phenotypes and place it in context with classical clinicopathological observations to provide mechanistic, clinical, and therapeutic insights into small vessel disease.