Conflict of interest: None declared.
Changes in fat mass in stroke survivors: a systematic review
Article first published online: 18 MAY 2012
© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization
International Journal of Stroke
Volume 7, Issue 6, pages 491–498, August 2012
How to Cite
English, C., Thoirs, K., Coates, A., Ryan, A. and Bernhardt, J. (2012), Changes in fat mass in stroke survivors: a systematic review. International Journal of Stroke, 7: 491–498. doi: 10.1111/j.1747-4949.2012.00824.x
Funding: Dr English is supported by a National Health and Medical Research Council Research Training Fellowship (#610312). Dr Ryan was supported by a VA Research Career Scientist Award, National Institute on Aging grants RO1-AG030075, and Claude D. Pepper Older Americans Independence Center P30-AG028747.
- Issue published online: 16 JUL 2012
- Article first published online: 18 MAY 2012
- National Health and Medical Research Council Research Training Fellowship. Grant Number: #610312
- VA Research Career Scientist Award, National Institute on Aging. Grant Number: RO1-AG030075
- Claude D. Pepper Older Americans Independence Center. Grant Number: P30-AG028747
- body composition;
- dual-energy X-ray absorpiometry;
- fat mass;
Stroke survivors have less muscle mass in their paretic limbs compared with nonparetic limbs, which may or may not be accompanied by changes in regional and/or whole body fat mass.
To examine the current evidence regarding differences in regional fat mass between paretic and nonparetic limbs and changes in whole body fat mass over time in stroke survivors.
A systematic search of relevant databases. Studies measuring whole body or regional fat mass using dual-energy X-ray absorpiometry, computed tomography, or magnetic resonance imaging were included.
Eleven trials were identified. Fat mass differences between paretic and nonparetic limbs and change in fat mass over time were not consistent. Meta-analyses were conducted using dual-energy X-ray absorpiometry-derived data from 10 trials (n = 324). There were no differences in fat mass between paretic and nonparetic legs (pooled mean difference 31·4 g, 95% confidence interval −33·9 to 96·6, P = 0·35), and slightly greater fat mass in the paretic arms compared with nonparetic arms (pooled mean difference 84·0 g, 95% confidence interval 30·7 to 137·3, P = 0·002). Whole body fat mass did not increase significantly between one-month and six-months poststroke (pooled mean difference 282·3 g, 95% confidence interval −824·4 to 1389, P = 0·62), but there was an increase between six- and 12 months poststroke (pooled mean difference 1935 g, 95% confidence interval 1031 to 2839, P < 0·001).
There were inconsistent findings regarding changes in fat mass after stroke. Large, well-designed studies are required to further investigate the impact of body composition changes on the health of stroke survivors.