Conflicts of interest: ME has received a research grant from AstraZeneca for studies with rosuvastatin.
Reduced risk of poststroke pneumonia in thrombolyzed stroke patients with continued statin treatment
Article first published online: 13 SEP 2012
© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization
International Journal of Stroke
Volume 10, Issue 1, pages 61–66, January 2015
How to Cite
Scheitz, J. F., Endres, M., Heuschmann, P. U., Audebert, H. J. and Nolte, C. H. (2015), Reduced risk of poststroke pneumonia in thrombolyzed stroke patients with continued statin treatment. International Journal of Stroke, 10: 61–66. doi: 10.1111/j.1747-4949.2012.00864.x
Funding: ME receives grant support from the Volkswagen Stiftung (Lichtenberg program to ME), Deutsche Forschungsgemeinschaft and German Ministry of Education and Research (Center for Stroke Research Berlin, CSB).
- Issue published online: 10 DEC 2014
- Article first published online: 13 SEP 2012
- Manuscript Accepted: 9 FEB 2012
- Manuscript Received: 17 NOV 2011
- Volkswagen Stiftung
- Deutsche Forschungsgemeinschaft
- German Ministry of Education and Research (Center for Stroke Research Berlin, CSB)
- ischemic stroke;
- respiratory infection;
Pneumonia is a frequent complication after stroke with strong impact on clinical outcome. Statins have pleiotropic immunmodulatory properties and were recently shown to exert beneficial effects on the development and clinical course of pneumonia.
We aimed to investigate whether statin use is associated with a reduced risk of poststroke pneumonia in acute ischemic stroke patients treated with tissue plasminogen activator within 4·5hours.
Data was extracted from a local register including all consecutive stroke patients who received thrombolysis at our institution. Prior statin use was identified retrospectively from clinical records and had to be continued after hospital admission. Poststroke pneumonia was diagnosed according to standardized criteria of US Centers for Disease Control and Prevention. Mortality and functional outcome at three-months were further assessed.
Overall, 481 ischemic stroke patients were analyzed. Continued statin use was documented in 17% of the patients. Frequency of pneumonia was 11%. Patients with statin use were less likely to develop poststroke pneumonia (5% vs. 13%, P = 0·04). After multivariable adjustment for known risk factors for poststroke pneumonia (age, stroke severity, dysphagia, male sex and diabetes), statin treatment was negatively associated with pneumonia (OR 0·31; 95% CI 0·10–0·94). Occurrence of pneumonia independently predicted three-month mortality and functional outcome.
Use of statins in acute ischemic stroke patients who receive thrombolysis might reduce the risk of poststroke pneumonia. Further studies are warranted to validate this finding.