Conflict of interest: None declared.
Risk of cardiovascular events and death in the life after aneurysmal subarachnoid haemorrhage: a nationwide study
Article first published online: 13 SEP 2012
© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization
International Journal of Stroke
Volume 9, Issue 8, pages 1090–1096, December 2014
How to Cite
Nieuwkamp, D. J., Vaartjes, I., Algra, A., Rinkel, G. J. E. and Bots, M. L. (2014), Risk of cardiovascular events and death in the life after aneurysmal subarachnoid haemorrhage: a nationwide study. International Journal of Stroke, 9: 1090–1096. doi: 10.1111/j.1747-4949.2012.00875.x
Funding: This study was in part funded by a grant from the Netherlands Organization for Health Research and Development (grant number 920-03-299) to D. J. N. and by a grant from The Netherlands Heart Foundation (project ‘Cardiovascular disease in the Netherlands – figures and facts’) to I. V.
- Issue published online: 10 NOV 2014
- Article first published online: 13 SEP 2012
- Netherlands Organization for Health Research and Development. Grant Number: 920-03-299
- The Netherlands Heart Foundation
- cardiovascular disease;
- cerebrovascular disease;
Background and aim
The increased mortality rates of survivors of aneurysmal subarachnoid haemorrhage have been attributed to an increased risk of cardiovascular events in a registry study in Sweden. Swedish registries have however not been validated for subarachnoid haemorrhage and Scandinavian incidences of cardiovascular disease differ from that in Western European countries. We assessed risks of vascular disease and death in subarachnoid haemorrhage survivors in the Netherlands.
From the Dutch hospital discharge register, we identified all patients with subarachnoid haemorrhage admission between 1997 and 2008. We determined the accuracy of coding of the diagnosis subarachnoid haemorrhage for patients admitted to our centre. Conditional on survival of three-months after the subarachnoid haemorrhage, we calculated standardized incidence and mortality ratios for fatal or nonfatal vascular diseases, vascular death, and all-cause death. Cumulative risks were estimated with survival analysis.
The diagnosis of nontraumatic subarachnoid haemorrhage was correct in 95·4% of 1472 patients. Of 11 263 admitted subarachnoid haemorrhage patients, 6999 survived more than three-months. During follow-up (mean 5·1 years), 874 (12·5%) died. The risks of death were 3·3% within one-year, 11·3% within five-years, and 21·5% within 10 years. The standardized mortality ratio was 3·4 (95% confidence interval: 3·1 to 3·7) for vascular death and 2·2 (95% confidence interval: 2·1 to 2·3) for all-cause death. The standardized incidence ratio for fatal or nonfatal vascular diseases was 2·7 (95% confidence interval: 2·6 to 2·8).
Dutch hospital discharge and cause of death registries are a valid source of data for subarachnoid haemorrhage, and show that the increased mortality rate in subarachnoid haemorrhage survivors is explained by increased risks for vascular diseases and death.