Conflict of interest: The authors declare that they have no competing interests.
Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events
Article first published online: 11 DEC 2012
© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization
International Journal of Stroke
Volume 8, Issue 7, pages 535–539, October 2013
How to Cite
Yi, X., Zhou, Q., Lin, J. and Chi, L. (2013), Aspirin resistance in Chinese stroke patients increased the rate of recurrent stroke and other vascular events. International Journal of Stroke, 8: 535–539. doi: 10.1111/j.1747-4949.2012.00929.x
- Issue published online: 11 SEP 2013
- Article first published online: 11 DEC 2012
- Scientific Research Foundation of Zhejiang Province Health Department. Grant Number: 2007A178
- aspirin resistance;
- cerebral infarction;
- recurrent stroke;
- vascular event
To investigate the prevalent of aspirin resistance (AR) in Chinese stroke patients and its association with recurrent stroke and other vascular events, including cardiovascular disease and death.
We prospectively enrolled 634 Chinese stroke patients. Aspirin was administrated to every patient from the first day of admission. Whole blood samples were collected for platelet aggregation testing after aspirin was administered for 7–10 days. A follow-up period of 12–24 months was performed to record vascular events and hemorrhagic side effects.
Aspirin resistance (AR) was detected in 129 patients (20·4%), aspirin semi-resistance (ASR) in 28 patients (4·4%) and aspirin sensitivity (AS) in 477 patients (75·2%). Logistic regression analysis found that diabetes and high levels of low density lipoprotein cholesterol (LDL) were independent risk factors for ASR and AR. During a median follow-up period of 19·4 months, the prevalence of recurrent stroke, death from all causes, myocardial infarction and vascular events overall were higher in patients with AR + ASR than in patients with AS. Cox regression analysis found that diabetes and AR were independent risk factors for vascular events.
Aspirin resistance is common in Chinese patient taking antiplatelet medications. Diabetes and high LDL may induce platelet activation and thrombosis and increase the occurrence of aspirin resistance. Patients who are detected to be aspirin resistant are at a greater risk of clinically important vascular events.