Conflicts of interest: None declared.
Excessive work and risk of haemorrhagic stroke: a nationwide case-control study
Article first published online: 11 DEC 2012
© 2012 The Authors. International Journal of Stroke © 2012 World Stroke Organization
International Journal of Stroke
Special Issue: World Stroke Day Edition 2013
Volume 8, Issue Supplement A100, pages 56–61, October 2013
How to Cite
Kim, B. J., Lee, S.-H., Ryu, W.-S., Kim, C. K., Chung, J.-W., Kim, D., Park, H.-K., Bae, H.-J., Park, B.-J., Yoon, B.-W. and ABBA study investigators (2013), Excessive work and risk of haemorrhagic stroke: a nationwide case-control study. International Journal of Stroke, 8: 56–61. doi: 10.1111/j.1747-4949.2012.00949.x
Funding: The ABBA study was primarily supported by the Korean Food and Drug Administration. This post hoc analysis was supported by research grants from the Korean Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (A102065, A110490). The analyses and interpretations of the data and the final content of the article were produced independent of the financial sponsors.
- Issue published online: 22 OCT 2013
- Article first published online: 11 DEC 2012
- Korean Food and Drug Administration
- Korean Health 21 R&D Project
- Ministry of Health and Welfare. Grant Numbers: A102065, A110490
- haemorrhagic stroke;
- intracerebral haemorrhage;
- sub-arachnoid haemorrhage;
- working condition;
- working hour
Adverse effect of excessive work on health has been suggested previously, but it was not documented in cerebrovascular diseases.
The authors investigated whether excessive working conditions would associate with increased risk of haemorrhagic stroke.
A nationwide matched case-control study database, which contains 940 cases of incident haemorrhagic stroke (498 intracerebral haemorrhages and 442 sub-arachnoid haemorrhages) with 1880 gender- and age- (±5-year) matched controls, was analysed. Work-related information based on the regular job situation, including type of occupation, regular working time, duration of strenuous activity during regular work and shift work, was gathered through face-to-face interviews. Conditional logistic regression analyses were used for the multivariable analyses.
Compared with white-collar workers, blue-collar workers had a higher risk for haemorrhagic stroke (odds ratio, 1·33 [95% confidence interval, 1·06–1·66]). Longer regular working time was associated with increased risk of haemorrhagic stroke [odds ratio, 1·38 (95% confidence interval, 1·05–1·81) for 8–12 h/day; odds ratio, 1·95 (95% confidence interval, 1·33–2·86) for ≥13 h/day; compared with ≤4 h/day]. Exposure to ≥8 h/week of strenuous activity also associated haemorrhagic stroke risk [odds ratio, 1·61 (95% confidence interval, 1·26–2·05); compared with no strenuous activity]. Shift work was not associated with haemorrhagic stroke (P = 0·98). Positive associations between working condition indices and haemorrhagic stroke risk were consistent regardless of haemorrhagic stroke sub-types and current employment status.
Blue-collar occupation, longer regular working time and extended duration of strenuous activity during work may relate to an increased risk of haemorrhagic stroke.