The Jordan River Basin is under great hydric stress. Increases in population and agricultural demand are contributing to the closure of the basin. This paper analyses the results of integrated water resources planning model (WEAP) by studying the vulnerability of water resources in the lower Jordan River under a changing climate pattern and growing water demands. Water balance models show that all aquifers supplying the city of Amman will be depleted within the next few decades. Mitigation measures should include the introduction of additional water into the basin through the Red Sea–Dead Sea canal, in addition to demand management measures such as water conservation and increase in irrigation efficiency. The findings of this study would provide a useful guide to the co-riparians for policy formulation, decision making and dispute resolution. Cooperation among the five riparian countries may be improved by building a Geographic Information System (GIS) database that provides access to accurate data for hydrological analysis.