In August 2001 a Potto Perodicticus potto was born in the Tropical Forest building of Franklin Park Zoo, Boston. The neonate was removed the following day for hand-rearing because its mother, which had a history of providing poor infant care, appeared to be neglecting it. Historically, Pottos in captivity have high rates of neonatal mortality that are frequently associated with maternal neglect. This paper gives detailed information about the methods used to hand-rear this infant successfully. Notes on infant development are presented and the health issues encountered, and medical treatments given, during the first few months are described.