The Limits of Firing Frequency in Cat Lumbosacral Motoneurones Possessing Different Time Course of Afterhyperpolarization



Kernell, D. The limits of firing frequency in cat lumbosacral motoneurones possessing different time course of after hyperpolarization. Acta physiol. scand. 1965. 65, 87–100. — Long-lasting repetitive discharges were set up in cat lumbosacral motoneurones by steady currents injected through the tip of an intracellular micro-electrode. The upper and lower limits of discharge frequency of the various motoneurones were significantly correlated with the time course of their afterhyperpolarization the latter being measured from single spike discharges (generally antidromic). From previous work it is known that the relation between discharge frequency and current strength (the “f-I relation”) is linear over a certain range from the minimal firing rate and upwards (Granit, Kernell and Shortess 1963, Kernell 1965 b). In the present paper it was shown that the maximal discharge frequency within this linear part of the f-I relation was also significantly correlated with the time course of afterhyperpolarization. The findings are discussed with regard to problems of regulation of muscle tension by repetitive firing on the part of the motoneurones.