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Abstract

Dinitrophenol strongly depresses salivary secretion and potassium uptake after acetylcholine-induced potassium loss in the perfused cat submandibular gland. However, transmembrane secretory potentials recorded from the acinar cells after intraarterial injections of acetylcholine change little after introduction of dinitrophenol. This seems to indicate that the secretory potentials are not directly dependent on energy metabolism and that the mechanism of these potential changes may be an increase in ion permeability of the basal acinar cell membrane.