Endotoxin-induced Suppression of Rabbit Kidney DOPA Decarboxylase Activity



The kinetic properties of the histamine-forming enzyme in the cortex of the rabbit kidney were found to be identical with those of DOPA decarboxylase. There was no evidence of “specific” histidine decarboxylase in the rabbit kidney cortex. Following i.v. injection of endotoxin, reduced DOPA decarboxylase activities were demonstrated after 3 and 6 hrs; after 24 hrs low as well as conspicuously high enzyme activities were observed.