The Effects of K+ -free Solution on Tension Development in the Smooth Muscle Taenia Coli from the Guinea Pig



In the smooth muscle taenia coli from guinea pig changes in the pattern of electrical and mechanical activity and their relationship occur in K+-free solutions. The ability to develop tension falls parallel with changes in intracellular concentrations of K' and Na'. The changes in mechanical properties are probably not according to interference with metabolic energy supply or more direct effects on the contractile components or passive mechanial properties. An interference with the normal functions of Ca2+ in the excitation-contraction coupling is suggested.