Anticholeretic effect of somatostatin in anesthetized dogs

Authors

  • Inger Holm,

    1. Department of Experimental Surgery, Karolinska Institutet, the Department of Surgery, Serafimerlasarettet, and the Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
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  • Lars Thulin,

    1. Department of Experimental Surgery, Karolinska Institutet, the Department of Surgery, Serafimerlasarettet, and the Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
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  • Hans Samnegård,

    1. Department of Experimental Surgery, Karolinska Institutet, the Department of Surgery, Serafimerlasarettet, and the Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
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  • Suad Efendic,

    1. Department of Experimental Surgery, Karolinska Institutet, the Department of Surgery, Serafimerlasarettet, and the Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
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  • Gunnar Tydén

    1. Department of Experimental Surgery, Karolinska Institutet, the Department of Surgery, Serafimerlasarettet, and the Department of Endocrinology, Karolinska Hospital, Stockholm, Sweden
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Summary.

Somatostatin, 0.2-1.0 βg. kg-l min-1, was administered i.v. in 5 anesthetized dogs. Following 9-min infusions, hepatic bile output was found to decrease by approximately 50% after a latency of 6 min. The mode of action suggests that somatostatin inhibits hormone-induced bile output.

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